4-CHLORO-8-METHYLQUINAZOLINE

Product Name: 4-CHLORO-8-METHYLQUINAZOLINE
CAS No.: 58421-80-0
Chemical Name: 4-CHLORO-8-METHYLQUINAZOLINE
Synonyms: 4-CHLORO-8-METHYLQUINAZOLINE;Quinazoline, 4-chloro-8-methyl-
CBNumber: CB0100342
Molecular Formula: C9H7ClN2
Formula Weight: 178.62
MOL File: 58421-80-0.mol

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4-CHLORO-8-METHYLQUINAZOLINE Property

Melting point:: 129-130 °C
Boiling point:: 298.2±20.0 °C(Predicted)
Density: 1.292
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.06±0.30(Predicted)
form: solid
color: Light yellow to yellow
InChI: InChI=1S/C9H7ClN2/c1-6-3-2-4-7-8(6)11-5-12-9(7)10/h2-5H,1H3
InChIKey: UTBDPFFXKANFFT-UHFFFAOYSA-N
SMILES: N1=C2C(C=CC=C2C)=C(Cl)N=C1

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Safety

Risk Statements: 36
Safety Statements: 26
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C602108
Product name: 4-Chloro-8-methylquinazoline
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C602108
Product name: 4-Chloro-8-methylquinazoline
Packaging: 500mg
Price: $200
Updated: 2021/12/16

TRC

Product number: C602108
Product name: 4-Chloro-8-methylquinazoline
Packaging: 1g
Price: $285
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-PY
Product name: 4-Chloro-8-methylquinazoline
Purity: 97%
Packaging: 1g
Price: $296
Updated: 2021/12/16

ChemScene

Product number: CS-W001047
Product name: 4-Chloro-8-methylquinazoline
Purity: ≥98.0%
Packaging: 5g
Price: $318
Updated: 2021/12/16

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4-CHLORO-8-METHYLQUINAZOLINE Chemical Properties,Usage,Production

Synthesis

19181-54-5

58421-80-0

General procedure for the synthesis of 4-chloro-8-methylquinazoline from 8-methyl-4-quinazolone: Phosphorus oxychloride (800 mL) was added to a 2 L round-bottomed flask under nitrogen protection. Subsequently, 8-methylquinazolin-4(3H)-one (125 g) was added in batches. The reaction mixture was heated to 120 °C and refluxed for 12 hours. The reaction process was monitored by thin layer chromatography (TLC) and liquid chromatography-mass spectrometry (LCMS). Upon completion of the reaction, the mixture was cooled to room temperature and evaporated to dryness under reduced pressure. The resulting residue was dissolved in dichloromethane (DCM, 500 mL) and quenched by slow pouring into a pre-cooled saturated potassium carbonate (K2CO3) solution under continuous stirring. The organic layer was separated, washed with brine, dried over anhydrous sodium sulfate, and subsequently concentrated under vacuum to afford 4-chloro-8-methylquinazoline (120 g, 86% yield) as a yellow solid. The product could be used for subsequent reactions without further purification. Mass spectrometry (MS) data: m/z = 179/181 [M + H]+.

References

[1] Patent: WO2017/106607, 2017, A1. Location in patent: Paragraph 00224
[2] Synthetic Communications, 2011, vol. 41, # 24, p. 3644 - 3653
[3] Patent: WO2013/106756, 2013, A2. Location in patent: Page/Page column 40
[4] Patent: US9822108, 2017, B2. Location in patent: Page/Page column 42
[5] Bioorganic and Medicinal Chemistry, 1996, vol. 4, # 8, p. 1203 - 1207

4-CHLORO-8-METHYLQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-8-METHYLQUINAZOLINE Suppliers

China 66 India 1 United Kingdom 3 United States 7 Global 77

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Tianjin Anhao Biological Technology Co., Ltd.

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View Lastest Price from 4-CHLORO-8-METHYLQUINAZOLINE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-CHLORO-8-METHYLQUINAZOLINE 58421-80-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-28

58421-80-0, 4-CHLORO-8-METHYLQUINAZOLINERelated Search:

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4-CHLORO-8-METHYLQUINAZOLINE

Quinazoline, 4-chloro-8-methyl-

58421-80-0

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Quinolines