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4-tert-Butylcyclohexanol

Product Name
4-tert-Butylcyclohexanol
CAS No.
98-52-2
Chemical Name
4-tert-Butylcyclohexanol
Synonyms
PATCHONE;Cyclohexanol, 4-(1,1-dimethylethyl)-;4-T-BUTYLCYCLOHEXANOL;Padaryl;usafdo-20;USAF do-20;PTB-Cyclohexanol;patchouli hexanol;4-tert-Butylcyclohex;P-T-BUTYLCYCLOHEXANOL
CBNumber
CB0105660
Molecular Formula
C10H20O
Formula Weight
156.27
MOL File
98-52-2.mol
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4-tert-Butylcyclohexanol Property

Melting point:
62-70 °C(lit.)
Boiling point:
110-115 °C15 mm Hg(lit.)
Density 
2.591
vapor pressure 
6-201.38Pa at 25-65℃
refractive index 
1.447
Flash point:
221 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
Powder or Granules
pka
15.32±0.40(Predicted)
color 
White
Odor
at 100.00 %. woody musty patchouli camphor mint leather
Odor Type
woody
Water Solubility 
<1 g/L (20 ºC)
BRN 
1902277
InChIKey
CCOQPGVQAWPUPE-UHFFFAOYSA-N
LogP
3.23 at 20℃
CAS DataBase Reference
98-52-2(CAS DataBase Reference)
NIST Chemistry Reference
Cyclohexanol, 4-(1,1-dimethylethyl)-(98-52-2)
EPA Substance Registry System
Cyclohexanol, 4-(1,1-dimethylethyl)- (98-52-2)
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Safety

Risk Statements 
23/25-33-50/53
Safety Statements 
24/25-61-60-45-28-20/21
RIDADR 
3256
WGK Germany 
1
RTECS 
GV8750000
HS Code 
29061900
Toxicity
The acute oral LD50 in rats was reported as 4-2 g/kg (3-62-4-87 g/kg)(Denine, 1973). The acute dermal LD50 in rabbits was reported as > 5 g/kg (Denine, 1973).
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B92001
Product name
4-tert-Butylcyclohexanol, mixture of cis and trans
Purity
98%
Packaging
100g
Price
$83
Updated
2023/01/07
TCI Chemical
Product number
B0383
Product name
4-tert-Butylcyclohexanol (cis- and trans- mixture)
Purity
>98.0%(GC)
Packaging
25g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
B0383
Product name
4-tert-Butylcyclohexanol (cis- and trans- mixture)
Purity
>98.0%(GC)
Packaging
500g
Price
$161
Updated
2025/07/31
TRC
Product number
D118005
Product name
4-(1,1-Dimethylethyl)cyclohexanol
Packaging
50g
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB14746
Product name
4-tert-Butylcyclohexanol, mixture of?cis?and?trans
Packaging
100g
Price
$60
Updated
2021/12/16
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4-tert-Butylcyclohexanol Chemical Properties,Usage,Production

Chemical Properties

It is white needle-shaped or powdery crystals with a woody, patchouli-like aroma.

Occurrence

Has apparently not been reported to occur in nature.

Uses

4-tert-Butylcyclohexanol (mixture of cis and trans) can be used as a reactant to synthesize tris(4,4′-di-tert-butyl-2,2′-bipyridine)(trans-4-tert-butylcyclohexanolato)deca-μ-oxido-heptaoxidoheptavanadium oxide cluster complex by reacting with [V8O20(C18H24N2)4]. It can also be used as a reactant in competitive Oppenauer oxidation experiments in the presence of zeolite BEA as a stereoselective catalyst. Only cis-isomer is selectively converted to the corresponding ketone, whereas trans-isomer remains unchanged.

Preparation

From 4-terf-butylphenol by hydrogenation(Arctander, 1969).

Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 2724, 1980 DOI: 10.1021/jo01301a040
Synthesis, p. 171, 1977 DOI: 10.1055/s-1977-24307

General Description

4-tert-Butylcyclohexanol is a soothing molecule whose special feature is to instantly decrease stinging and burning sensations. According to the manufacturer's impressive numbers, it can reduce stinging up to 78% and burning sensation by up to 80% after just 3 minutes.
It is so effective because it works at a cellular level via intercepting the signals caused by the irritation before they can reach the neuro-receptor. This means that we feel stinging and burning sensations much less and the skin's tolerance threshold is increased.
The effectiveness of SymSitive was also backed up by a comparative study. It found that both 4‐t‐Butylcyclohexanol and fellow cell-communicating, soothing molecule acetyl dipeptide‐1 cetyl ester works, but 4‐t‐Butylcyclohexanol works better.

Synthesis

Phenol and isobutylene carry out tert-butylation reaction in the presence of aluminum trichloride, and catalytic hydrogenation with Rays Nickel W7, two kinds of geometric structures can be obtained, in which the trans structure accounts for more than 70%.

References

[1] Patent: US6388149, 2002, B2. Location in patent: Page column 17
[2] Patent: US6388149, 2002, B2. Location in patent: Page column 17
[3] RSC Advances, 2014, vol. 4, # 6, p. 2729 - 2732
[4] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1911, vol. 152, p. 609
[5] Journal of applied chemistry of the USSR, 1984, vol. 57, # 10 pt 2, p. 2138 - 2142

4-tert-Butylcyclohexanol Preparation Products And Raw materials

Raw materials

Preparation Products

4-TERT-BUTYLCYCLOHEXANECARBOXYLIC ACID 4-tert-Butylcyclohexanone 1-ethynyl-4-tert-butyl-cyclohexan-1-ol
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4-tert-Butylcyclohexanol Suppliers

Americas 1 Australia 1 Belgium 3 Brazil 1 China 290 Czech Republic 1 Europe 1 France 3 Germany 11 India 17 Japan 6 Mexico 1 Slovakia 1 Spain 2 Switzerland 2 The Netherlands 2 United Kingdom 14 United States 57 USA 1 Global 415
Cheng Du Micxy Chemical Co.,Ltd
Tel
028-85632863 18108198598
Fax
028-85632863
Email
micxysales@163.com
Country
China
ProdList
10475
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58
Hubei Qifei Pharmaceutical Chemical Co., Ltd
Tel
027-59322506 18071128681
Fax
027-59322506
Email
1438082200@qq.com
Country
China
ProdList
9927
Advantage
58
Guangzhou Aiyu Technology Co.,Ltd
Tel
18588406486
Email
courage.you@foxmail.com
Country
China
ProdList
206
Advantage
58
Hubei Junrui Biotechnology Co., Ltd
Tel
13971166412
Email
2653908223@qq.com
Country
China
ProdList
4996
Advantage
58
Hubei Xingyao Biomedical Technology Co., Ltd
Tel
17762494339
Email
3645778939@qq.com
Country
China
ProdList
4988
Advantage
58
ZHENYOU LIAO (WUHAN) BIOTECHNOLOGY CO., LTD.
Tel
18062454418
Email
857732885@qq.com
Country
China
ProdList
102
Advantage
58
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com
Country
China
ProdList
613
Advantage
60
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Changzhou Sunlight Pharmaceutical Co., Ltd
Tel
519-83131668 15995063688
Fax
+86-519-83138041
Email
info@sunlightchem.com
Country
China
ProdList
99
Advantage
69
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-021-61259138 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
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View Lastest Price from 4-tert-Butylcyclohexanol manufacturers

Sichuan Zhuoyu Yantang Technology Co., Ltd.
Product
4-tert-Butylcyclohexanol 98-52-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2025-08-08
Hebei Fengjia New Material Co., Ltd
Product
4-t-BUTYLCYCLOHEXANOL 98-52-2
Price
US $5.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2024-08-08
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-tert-Butylcyclohexanol 98-52-2
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-11

98-52-2, 4-tert-ButylcyclohexanolRelated Search:

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  • Organic Building Blocks
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