Benzaldehyde, 4-ethyl-2-hydroxy- (9CI)
- Product Name
- Benzaldehyde, 4-ethyl-2-hydroxy- (9CI)
- CAS No.
- 161876-64-8
- Chemical Name
- Benzaldehyde, 4-ethyl-2-hydroxy- (9CI)
- Synonyms
- 4-Ethylsalicylaldehyde;5-ethyl-2-formylphenol;4-ethyl-2-hydroxybenzaldehyde;Benzaldehyde, 4-ethyl-2-hydroxy-;Benzaldehyde, 4-ethyl-2-hydroxy- (9CI)
- CBNumber
- CB01060058
- Molecular Formula
- C9H10O2
- Formula Weight
- 150.17
- MOL File
- 161876-64-8.mol
Benzaldehyde, 4-ethyl-2-hydroxy- (9CI) Property
- Boiling point:
- 247.3±20.0 °C(Predicted)
- Density
- 1.134±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.27±0.10(Predicted)
- Appearance
- Light yellow to yellow Liquid
Safety
- HS Code
- 2914500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6202CR
- Product name
- 4-Ethylsalicylaldehyde
- Packaging
- 1g
- Price
- $262
- Updated
- 2021/12/16
- Product number
- 6202CR
- Product name
- 4-Ethylsalicylaldehyde
- Packaging
- 10g
- Price
- $971
- Updated
- 2021/12/16
- Product number
- 2715-1-57
- Product name
- 4-Ethylsalicylaldehyde
- Packaging
- 5G
- Price
- $1008
- Updated
- 2021/12/16
- Product number
- A147221
- Product name
- 4-Ethylsalicylaldehyde
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- A147221
- Product name
- 4-Ethylsalicylaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $238
- Updated
- 2021/12/16
Benzaldehyde, 4-ethyl-2-hydroxy- (9CI) Chemical Properties,Usage,Production
Synthesis
620-17-7
4885-02-3
161876-64-8
532967-00-3
To a solution of 3-ethylphenol (6.11 g, 50 mmol) was sequentially added titanium (IV) chloride (100 ml, 100 mmol, 1 M solution in dichloromethane) and 1,1-dichlorodimethyl ether (7.47 ml, 82.5 mmol) at 0 °C. The reaction mixture was stirred at 0°C for 45 minutes. After completion of the reaction, the mixture was poured into ice water and extracted with ethyl acetate (EtOAc). The organic layer was washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a bright pink oil. Purification by fast column chromatography (eluent: hexane/ethyl acetate, 0 to 10% gradient) afforded 4-ethyl-2-hydroxybenzaldehyde (4.9 g, 65% yield) by first elution, followed by 2-ethyl-4-hydroxybenzaldehyde (1.32 g, 18% yield) by subsequent elution. 1H NMR (400 MHz, CDCl3) data of product A: δ 1.25 (t, J=7.6 Hz, 3H), 2.67 (d, J=7.6 Hz, 2H), 6.82 (s, 1H), 6.85 (d, J=8.0 Hz, 1H), 7.46 (t, J=8.0 Hz, 1H), 9.83 (s, 1H), 11.05 (s, 1H). 1H NMR (400 MHz, CDCl3) data of product B: δ 1.27 (t, J=7.6Hz, 3H), 3.03 (d, J=7.6Hz, 2H), 6.68 (s, 1H), 6.78 (s, 1H), 6.82 (d, J=8.3Hz, 1H), 7.77 (t, J=8.3Hz, 1H), 10.10 (s, 1H).
References
[1] Patent: WO2006/18725, 2006, A1. Location in patent: Page/Page column 120-121
Benzaldehyde, 4-ethyl-2-hydroxy- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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