5-Bromo-2-iodopyridine
- Product Name
- 5-Bromo-2-iodopyridine
- CAS No.
- 223463-13-6
- Chemical Name
- 5-Bromo-2-iodopyridine
- Synonyms
- 2-IODO-5-BROMOPYRIDINE;CAS:223463-13-6;5-Brom-2-iodpyridin;5-bromo-2-lodopyridine;5-BROMO-2-IDIOPYRIDINE;5-BROMO-2-IODOPYRIDINE;5-CroMo-2-iodopyridine;2-iodine-5-broMopyridine;PYRIDINE, 5-BROMO-2-IODO-;5-Bromo-2-Iodopyridine99%
- CBNumber
- CB0111175
- Molecular Formula
- C5H3BrIN
- Formula Weight
- 283.89
- MOL File
- 223463-13-6.mol
5-Bromo-2-iodopyridine Property
- Melting point:
- 113-117 °C (lit.)
- Boiling point:
- 258.8±20.0 °C(Predicted)
- Density
- 2.347±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO, Methanol (Slightly)
- pka
- -0.51±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to beige
- Sensitive
- Light Sensitive
- BRN
- 2119
- Stability:
- Light Sensitive
- InChI
- InChI=1S/C5H3BrIN/c6-4-1-2-5(7)8-3-4/h1-3H
- InChIKey
- HSNBRDZXJMPDGH-UHFFFAOYSA-N
- SMILES
- C1(I)=NC=C(Br)C=C1
- CAS DataBase Reference
- 223463-13-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, LIGHT SENSITIVE
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 569607
- Product name
- 5-Bromo-2-iodopyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $44.52
- Updated
- 2025/07/31
- Product number
- 569607
- Product name
- 5-Bromo-2-iodopyridine
- Purity
- 97%
- Packaging
- 25g
- Price
- $80.5
- Updated
- 2025/07/31
- Product number
- B2877
- Product name
- 5-Bromo-2-iodopyridine
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $47
- Updated
- 2025/07/31
- Product number
- B2877
- Product name
- 5-Bromo-2-iodopyridine
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $186
- Updated
- 2025/07/31
- Product number
- B687630
- Product name
- 5-Bromo-2-iodopyridine
- Packaging
- 10g
- Price
- $65
- Updated
- 2021/12/16
5-Bromo-2-iodopyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
5-Bromo-2-iodopyridine may be used in the synthesis of the following:
- 5-bromopyridyl-2-magnesium chloride via reaction with isopropylmagnesium chloride solution
- 5-bromo-2-pyridylzinc iodide via treatment with active zinc in tetrahydrofuran
- 5-bromo-2-(trifluoromethyl)pyridine via halogen/trifluoromethyl displacement reaction
- (5-bromopyridin-2-yl)zinc(II) chloride via multi-step synthesis
- 5,5′-dibromo-2,2′-bipyridine via multi-step synthesis
Synthesis
624-28-2
223463-13-6
The general procedure for the synthesis of 5-bromo-2-iodopyridine from 2,5-dibromopyridine was as follows: an aqueous solution of 57% hydriodic acid (HI) was added to a reaction system containing 2,5-dibromopyridine (12.60 g, 53.2 mmol) and sodium iodide (NaI, 11.40 g, 76 mmol). The reaction mixture was heated to reflux for 24 h, subsequently cooled to room temperature and diluted with 100 mL of water. The pH of the mixture was adjusted to alkaline with sodium bicarbonate (NaHCO3), and then treated with the addition of sodium dithionite (Na2S2O4) until the solution became colorless. The reaction mixture was extracted with dichloromethane (DCM, 5 x 60 mL), the organic phases were combined and dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure and the obtained residue was collected by filtration, washed with ether (Et2O, 60 mL) and dried over air to give 5-bromo-2-iodopyridine (8.28 g, 55% yield) as a light gray powder.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 17, p. 4528 - 4532
[2] Chemical Communications, 2012, vol. 48, # 8, p. 1120 - 1122
[3] European Journal of Organic Chemistry, 2003, # 8, p. 1559 - 1568
[4] Journal of Organic Chemistry, 2001, vol. 66, # 2, p. 605 - 608
[5] Organic Letters, 2004, vol. 6, # 26, p. 4905 - 4907
5-Bromo-2-iodopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-2-iodopyridine Suppliers
- Tel
- --
- Fax
- --
- synthesis@bujno.com.pl
- Country
- Poland
- ProdList
- 264
- Advantage
- 38
View Lastest Price from 5-Bromo-2-iodopyridine manufacturers
- Product
- 5-Bromo-2-iodopyridine 223463-13-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2025-08-21
- Product
- 5-Bromo-2-iodopyridine 223463-13-6
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100000
- Release date
- 2024-08-08
- Product
- 5-Bromo-2-iodopyridine 223463-13-6
- Price
- US $8.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-22