ChemicalBook > CAS DataBase List > Thalidomide-NH-PEG1-NH-Boc
Thalidomide-NH-PEG1-NH-Boc
- Product Name
- Thalidomide-NH-PEG1-NH-Boc
- CAS No.
- 2154342-17-1
- Chemical Name
- Thalidomide-NH-PEG1-NH-Boc
- Synonyms
- Thalidomide-NH-PEG1-NH-Boc;Thalidomide-4-NH-PEG1-NH-Boc;Thalidomide-4-NH-PEG1-C2-NH-Boc;tert-butyl (2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)carbamate;Carbamic acid, N-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB011336433
- Molecular Formula
- C22H28N4O7
- Formula Weight
- 460.48
- MOL File
- 2154342-17-1.mol
More
Less
Thalidomide-NH-PEG1-NH-Boc Property
- Boiling point:
- 715.3±60.0 °C(Predicted)
- Density
- 1.346±0.06 g/cm3(Predicted)
- pka
- 10.74±0.40(Predicted)
More
Less
Thalidomide-NH-PEG1-NH-Boc Chemical Properties,Usage,Production
Uses
Thalidomide-4-NH-PEG1-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-4-NH-PEG1-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG1-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
IC 50
Cereblon
References
[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527
Thalidomide-NH-PEG1-NH-Boc Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Thalidomide-NH-PEG1-NH-Boc Suppliers
- Tel
- 021-50460086-9 15921403865
- Fax
- +86-21-50462321
- han_yajun@dctc.daicel.com
- Country
- China
- ProdList
- 7471
- Advantage
- 65
- Tel
- +8613062833949
- fred.wen@crcorporation.cn
- Country
- China
- ProdList
- 8645
- Advantage
- 58
- Tel
- 0371-0371-53736046 13393710386
- Fax
- QQ:2853979814
- 2853979814@qq.com
- Country
- China
- ProdList
- 9947
- Advantage
- 58
- Tel
- 15092083467
- 18660263263@163.com
- Country
- China
- ProdList
- 2810
- Advantage
- 58
- Tel
- 400-400-6966-012-012 17778955912
- 2957605606@qq.com
- Country
- China
- ProdList
- 2535
- Advantage
- 58
- Tel
- 13558691827
- yuxinpharma@126.com
- Country
- China
- ProdList
- 95
- Advantage
- 58
- Tel
- 15927323052
- shenqianyan@prssh.com
- Country
- China
- ProdList
- 999
- Advantage
- 58
- Tel
- 19353112242
- 1816280386@qq.com
- Country
- China
- ProdList
- 8045
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 11973
- Advantage
- 58
- Tel
- 18143011203
- ET-market@chemextension.com
- Country
- China
- ProdList
- 32034
- Advantage
- 58
More
Less
View Lastest Price from Thalidomide-NH-PEG1-NH-Boc manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- Thalidomide-NH-PEG1-NH-Boc 2154342-17-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-08
2154342-17-1, Thalidomide-NH-PEG1-NH-BocRelated Search:
tert-butyl (8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)carbamate
N-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-carbamic Acid 1,1-Dimethylethyl Ester
Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester
4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-, 1,1-dimethylethyl ester
Thalidomide-NH-C3-NH-Boc
N-[2-Aminoethyl] Pomalidomide Trifluoroacetic Acid Salt
Carbamic acid, N-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-, 1,1-dimethylethyl ester