ChemicalBook > CAS DataBase List > 2-Methyl-2-propyl-1,3-propanediol
2-Methyl-2-propyl-1,3-propanediol
Synthesis- Product Name
- 2-Methyl-2-propyl-1,3-propanediol
- CAS No.
- 78-26-2
- Chemical Name
- 2-Methyl-2-propyl-1,3-propanediol
- Synonyms
- DURANOL;NSC 26233;Dimethylolpentane,97%;Pentane-2,2-dimethanol;2,2-DIMETHYLOL-PENTANE;Carisoprodol iMpurity C;Carisoprodol EP Impurity C;Carisoprodol intermediate H;2,2-BIS(HYDROXYMETHYL)PENTANE;2-methyl-2-propyl-3-propanediol
- CBNumber
- CB0114707
- Molecular Formula
- C7H16O2
- Formula Weight
- 132.2
- MOL File
- 78-26-2.mol
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2-Methyl-2-propyl-1,3-propanediol Property
- Melting point:
- 57-59 °C (lit.)
- Boiling point:
- 230 °C/753 mmHg (lit.)
- Density
- 0.9744 (rough estimate)
- refractive index
- 1.4474 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 14.57±0.10(Predicted)
- form
- Solid
- color
- White
- BRN
- 1734432
- CAS DataBase Reference
- 78-26-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 1,3-Propanediol, 2-methyl-2-propyl-(78-26-2)
- EPA Substance Registry System
- 1,3-Propanediol, 2-methyl-2-propyl- (78-26-2)
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Safety
- Hazard Codes
- Xn
- Risk Statements
- 36-22
- Safety Statements
- 22-24/25-39-26
- WGK Germany
- 1
- RTECS
- TY9386000
- HS Code
- 2905399590
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- M75209
- Product name
- 2-Methyl-2-propyl-1,3-propanediol
- Purity
- 98%
- Packaging
- 25g
- Price
- $46.8
- Updated
- 2024/03/01
TCI Chemical
- Product number
- D0766
- Product name
- 2-Methyl-2-propyl-1,3-propanediol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $23
- Updated
- 2024/03/01
TCI Chemical
- Product number
- D0766
- Product name
- 2-Methyl-2-propyl-1,3-propanediol
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $218
- Updated
- 2024/03/01
Usbiological
- Product number
- 282563
- Product name
- 2-Methyl-2-propyl-1,3-propanediol
- Packaging
- 25g
- Price
- $292
- Updated
- 2021/12/16
TRC
- Product number
- M320590
- Product name
- 2-Methyl-2-propyl-1,3-propanediol
- Packaging
- 250g
- Price
- $155
- Updated
- 2021/12/16
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2-Methyl-2-propyl-1,3-propanediol Chemical Properties,Usage,Production
Synthesis
2-Methyl-2-pentenal was hydrogenated at 100°C and 1.3-1.5MPa with a yield of 80%. After obtaining 2-methylpentenal, it was added to 36% formaldehyde, and the reaction was carried out at room temperature. Sodium hydroxide solution was added dropwise. The reaction was exothermic, and the temperature was naturally raised to 70 °C, then heated to 90 °C, added for 1 h, cooled to 60 °C and left to separate layers. The upper layer was washed with water, the washings were combined with the lower layer, and extracted with benzene. The extract and the upper layer were combined, and benzene was recovered by distillation, followed by distillation under reduced pressure to collect a fraction at 160°C (14.7kPa), which was 2-methyl-2-propyl-1,3-propanediol,yield 93%.
Description
2-Methyl-2-propyl-1,3-propanediol is produced either by the salt-free procedure based on aldol addition followed by hydrogenation or by the classical combination of hydroxymethylation and Cannizzaro-type disproportionation with formaldehyde. The production costs are considerably higher than for neopentyl glycol, because the synthesis of 2-methylpentanal from propanal requires two additional steps: aldol condensation and hydrogenation.
Chemical Properties
Whgite Crystalline Solid
Uses
An intermediate in the synthesis of Carisoprodol.
Uses
2-Methyl-2-propyl-1,3-propanediol is mainly used in pharmaceutical applications such as production of dicarbamates. Meprobamate (2-methyl-2-propyl-1,3-propanediol dicarbamate), is used as an anxiolytic drug (tranquilizer). Carisoprodol (N-isopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate), possesses strong centrally-acting muscle relaxant activity.
2-Methyl-2-propyl-1,3-propanediol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methyl-2-propyl-1,3-propanediol manufacturers
Hebei Zhanyao Biotechnology Co. Ltd
- Product
- 2-Methyl-2-Propyl-1,3-Propanediol 78-26-2
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-11
Wuhan Monad Medicine Tech Co.,LTD
- Product
- 2-Methyl-2-propyl-1,3-propanediol 78-26-2
- Price
- US $10.00/KG
- Min. Order
- 25Kg/Drum
- Purity
- 99.99%
- Supply Ability
- 20 tons/month
- Release date
- 2020-12-25
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 2-Methyl-2-propyl-1,3-propanediol 78-26-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-10
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