METHYL 6-QUINOLINEACETATE

Product Name: METHYL 6-QUINOLINEACETATE
CAS No.: 5622-36-6
Chemical Name: METHYL 6-QUINOLINEACETATE
Synonyms: Methyl 2-(quinolin-6-yl);METHYL 6-QUINOLINEACETATE;methyl quinolin-6-ylacetate;Methyl 2-quinolin-6-ylacetate;Methyl 6-quinolineacetate ,95%;6-Quinolineacetic acid methyl ester;Quinolin-6-Yl-Acetic Acid Methyl Ester
CBNumber: CB0121284
Molecular Formula: C12H11NO2
Formula Weight: 201.22
MOL File: 5622-36-6.mol

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METHYL 6-QUINOLINEACETATE Property

Boiling point:: 196-200 °C(Press: 13 Torr)
Density: 1.186±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 4.82±0.10(Predicted)
Appearance: Light yellow to brown Liquid
CAS DataBase Reference: 5622-36-6

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M320988
Product name: Methyl2-(Quinolin-6-yl)acetate
Packaging: 500mg
Price: $105
Updated: 2021/12/16

AK Scientific

Product number: X7063
Product name: Methyl6-quinolineacetate
Packaging: 10g
Price: $652
Updated: 2021/12/16

AK Scientific

Product number: X7063
Product name: Methyl6-quinolineacetate
Packaging: 25g
Price: $1226
Updated: 2021/12/16

Labseeker

Product number: SC-27553
Product name: Methyl6-Quinolineacetate
Purity: 95
Packaging: 25g
Price: $1467
Updated: 2021/12/16

Ambeed

Product number: A221429
Product name: Methyl2-(quinolin-6-yl)acetate
Purity: 98%
Packaging: 100mg
Price: $22
Updated: 2021/12/16

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METHYL 6-QUINOLINEACETATE Chemical Properties,Usage,Production

Uses

Methyl 2-(Quinolin-6-yl)acetate is a reactuant to prepare triazolopyridazines as tyrosine kinase modulators.

Synthesis

67-56-1

5622-34-4

5622-36-6

Example 1. Preparation of methyl quinoline-6-acetate: Concentrated sulfuric acid (206 mL, 3.868 mol) was slowly added dropwise to a solution of 6-quinolineacetic acid (Compound 1001, 658.2 g, 3.516 mol, Okeanos Tech Co., Catalog No. OK-J-05024) dissolved in 6.5 L of methanol as shown in step i of Scheme 1. A slight exotherm was observed during the dropwise addition. After dropwise addition, the reaction mixture was stirred under reflux conditions for 4 hours. After completion of the reaction, it was cooled to room temperature and the volatile solvent was removed by distillation under reduced pressure. The residue was diluted with 4 L of ethyl acetate and cooled in an ice bath. Subsequently, the pH was adjusted to 4 with 2 N NaOH solution (2.1 L, 1.2 eq.) and then with saturated sodium bicarbonate solution to 8. The organic and aqueous layers were separated and the aqueous layer was extracted twice with ethyl acetate. The combined organic phases were washed sequentially with saturated sodium bicarbonate solution, water and brine, and then dried with anhydrous MgSO4. After filtration, the solvent was evaporated under reduced pressure to give methyl quinoline-6-acetate (compound 1002, 696.8 g, 98% yield) as a clear brown oil: ESMS (M + 1), 202.14; 1H NMR (300.0 MHz, DMSO-d6) δ 8.90 (1H, dd, J = 1.7, 4.2 Hz), 8.14-8.10 (1H , m), 8.08 (1H, d, J = 8.7 Hz), 7.72 (1H, d, J = 1.4 Hz), 7.65 (1H, dd, J = 2.0, 8.7 Hz), 7.40 (1H, dd, J = 4.2, 8.3 Hz), 3.83 (2H, s), 3.73 (3H, s).

References

[1] Patent: WO2010/59668, 2010, A1. Location in patent: Page/Page column 20-21
[2] Patent: WO2016/8011, 2016, A1. Location in patent: Page/Page column 67
[3] Patent: WO2013/19682, 2013, A1. Location in patent: Page/Page column 117
[4] Patent: WO2008/144767, 2008, A1. Location in patent: Page/Page column 110; 115
[5] Journal of Medicinal Chemistry, 2013, vol. 56, # 17, p. 6651 - 6665

METHYL 6-QUINOLINEACETATE Preparation Products And Raw materials

Raw materials

Glycerol 4-Aminophenylacetic acid Methanol Nitrobenzene Sodium hydroxide Ferrous sulfate heptahydrate Sulfuric acid

Preparation Products

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METHYL 6-QUINOLINEACETATE Suppliers

China 66 India 1 United Kingdom 1 United States 6 Global 74

Accela ChemBio Inc.

Tel: +1(858) 699-3322
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Country: United States
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Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
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Aladdin Scientific

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Country: United States
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Synthonix Inc

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Email: info@synthonix.com
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ProdList: 6872
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Aagile Labs Division of Tyger Scientific

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Email: tygersci@yahoo.com
Country: United States
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APAC Pharmaceutical, LLC

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Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

5622-36-6, METHYL 6-QUINOLINEACETATERelated Search:

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METHYL 6-QUINOLINEACETATE

Quinolin-6-Yl-Acetic Acid Methyl Ester

Methyl 6-quinolineacetate ,95%

Methyl 2-quinolin-6-ylacetate

6-Quinolineacetic acid methyl ester

Methyl 2-(quinolin-6-yl)

methyl quinolin-6-ylacetate

5622-36-6

pharmacetical

Heterocycles

Acids and Derivatives