1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-

Product Name: 1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-
CAS No.: 2447587-73-5
Chemical Name: 1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-
Synonyms: VEGFR-2-IN-22;1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-
CBNumber: CB012732739
Molecular Formula: C26H24ClFN4O6
Formula Weight: 542.94
MOL File: 2447587-73-5.mol

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1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)- Property

Density: 1.36±0.1 g/cm3(Predicted)
pka: 9.65±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)- Chemical Properties,Usage,Production

Uses

VEGFR-2-IN-22 (Compound 25) is a dual VEGFR-2 and β-tubulin polymerization inhibitor with an IC50 of 19.82 nM against VEGFR-2. VEGFR-2-IN-22 induces apoptosis[1].

IC 50

VEGFR2: 19.82 nM (IC₅₀)

References

[1] Abdelhameid MK, et al. Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells). Bioorg Chem. 2020 Aug;101:103995. DOI:10.1016/j.bioorg.2020.103995

1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)- Suppliers

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2447587-73-5, 1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-Related Search:

Quinazoline, 4-[(4-bromophenyl)methoxy]- VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi) 3-nitro-N-(8-quinolinyl)benzamide 2-Quinazolinecarboxylic acid, 4-[3-fluoro-4-[[[(3-methylphenyl)amino]carbonyl]amino]phenoxy]-, ethyl ester Pazopanib Impurity 3 Benzoic acid, 4-[[4-[[2-[2,4-dioxo-5-(phenylmethylene)-3-thiazolidinyl]acetyl]amino]benzoyl]amino]-, ethyl ester VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated 3-Pyridinecarbonitrile, 2-hydrazinyl-6-(2-naphthalenyl)-4-(4-nitrophenyl)- 2,4-PyriMidinediaMine with linker

1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-

VEGFR-2-IN-22

2447587-73-5

C26H24ClFN4O6