ChemicalBook > CAS DataBase List > (S)-(-)-2-Azetidinecarboxylic acid

(S)-(-)-2-Azetidinecarboxylic acid

Product Name
(S)-(-)-2-Azetidinecarboxylic acid
CAS No.
2133-34-8
Chemical Name
(S)-(-)-2-Azetidinecarboxylic acid
Synonyms
(S)-AZETIDINE-2-CARBOXYLIC ACID;H-AZE-OH;L-AZETIDINE-2-CARBOXYLIC ACID;L-H-Aze-OH;H-AZE(2)-OH;(S)-(-)-2-Azetidinec;N,3-Methylene-L-alanine;L-AZETIDINECARBOXYLIC ACID;l-2-azetidinecarboxylicaci;azetidyl-2-carboxylic acid
CBNumber
CB0128117
Molecular Formula
C4H7NO2
Formula Weight
101.1
MOL File
2133-34-8.mol
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(S)-(-)-2-Azetidinecarboxylic acid Property

Melting point:
~215 °C (dec.)
alpha 
-125 º (c=1, water 25 ºC)
Boiling point:
189.47°C (rough estimate)
Density 
1.2245 (rough estimate)
refractive index 
-122 ° (C=4, H2O)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Aqueous Base (Slightly), Methanol (Slightly), Water (Slightly)
pka
2.35±0.20(Predicted)
form 
Crystalline Powder or Crystals
color 
White to light beige
Water Solubility 
5 g/100 mL
Merck 
14,908
BRN 
80678
InChIKey
IADUEWIQBXOCDZ-VKHMYHEASA-N
CAS DataBase Reference
2133-34-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
RTECS 
CM4310500
Hazard Note 
Irritant
HS Code 
29339900
Hazardous Substances Data
2133-34-8(Hazardous Substances Data)
Toxicity
LD50 scu-mus: 1000 mg/kg 85GDA2 8(1),101,82
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A0760
Product name
L-Azetidine-2-carboxylic acid
Purity
≥99%
Packaging
50mg
Price
$85.9
Updated
2024/03/01
Sigma-Aldrich
Product number
A0760
Product name
L-Azetidine-2-carboxylic acid
Purity
≥99%
Packaging
1g
Price
$711
Updated
2024/03/01
TCI Chemical
Product number
A1043
Product name
L-Azetidine-2-carboxylic Acid [Antagonist of L-Proline]
Purity
>98.0%(T)
Packaging
1g
Price
$279
Updated
2024/03/01
TCI Chemical
Product number
A1043
Product name
L-Azetidine-2-carboxylic Acid [Antagonist of L-Proline]
Purity
>98.0%(T)
Packaging
100mg
Price
$49
Updated
2024/03/01
Alfa Aesar
Product number
L09668
Product name
(S)-(-)-Azetidine-2-carboxylic acid, 98%
Packaging
250mg
Price
$120.65
Updated
2024/03/01
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(S)-(-)-2-Azetidinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Specific proline antagonist. Used in synthesis of abnormally high molecular weight polypeptides.

Uses

L-Azetidine-2-carboxylic acid has been used as a:

  • collagen synthesis inhibitor
  • protein folding antagonist
  • as a standard in liquid chromatography-mass spectrometry

Uses

(S)-(-)-2-Azetidinecarboxylic acid is a four-membered ring analog of L-Proline, It is a useful intermediate in the synthesis of polypeptides,Used in synthesis of abnormally high molecular weight polypeptides.

Definition

ChEBI: The (S)-enantiomer of azetidine-2-carboxylic acid.

General Description

L-Azetidine-2-carboxylic acid is a non-protein amino acid and teratogenic agent. It is toxic in nature.

Biochem/physiol Actions

Azetidine-2-carboxylic acid (AZC) triggers protein aggregation or upregulates the expression of an aggregation-prone mutant protein, upon interference with nascent protein folding.

Safety Profile

Moderately toxic by subcutaneousroute. An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits toxic fumes of NOx.

(S)-(-)-2-Azetidinecarboxylic acid Preparation Products And Raw materials

Raw materials

Potassium tert-butoxide Acetonitrile 2-Bromoethanol Potassium carbonate Palladium L-1-Phenylethylamine Tetrahydrofuran Diethyl ether Ammonium chloride Ethyl acetate Hydrochloric acid Bromoacetonitrile Sodium bicarbonate Dichloromethane Methanol Dimethyl sulfoxide Thionyl chloride PETROLEUM ETHER

Preparation Products

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View Lastest Price from (S)-(-)-2-Azetidinecarboxylic acid manufacturers

Honest Joy Holdings Limited
Product
(S)-L-Azetidine-2-carboxylic acid 2133-34-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
100 tons
Release date
2022-01-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
(S)-(-)-2-Azetidinecarboxylic acid 2133-34-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
L-Azetidine-2-carboxylic Acid [Antagonist of L-Proline] 2133-34-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

2133-34-8, (S)-(-)-2-Azetidinecarboxylic acidRelated Search:

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  • BioChemical
  • Cell Signaling and Neuroscience
  • Extracellular Matrix
  • Cytoskeleton and Extracellular Matrix
  • Others
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis
  • Amino Acids 13C, 2H, 15N
  • Carboxylic Acids (Chiral)