20-carboxyarachidonic acid

Product Name: 20-carboxyarachidonic acid
CAS No.: 79551-84-1
Chemical Name: 20-carboxyarachidonic acid
Synonyms: 20-carboxyarachidonic acid;(5Z,8Z,11Z,14Z)-icosatetraenedioic acid;5(Z),8(Z),11(Z),14(Z)-eicosatetraenedioic acid;5,8,11,14-Eicosatetraenedioic acid, (5Z,8Z,11Z,14Z)-
CBNumber: CB01314573
Molecular Formula: C20H30O4
Formula Weight: 334.45
MOL File: 79551-84-1.mol

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20-carboxyarachidonic acid Property

Boiling point:: 500.7±38.0 °C(Predicted)
Density: 1.037±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: 0.1 M Na2CO3: 1.5 mg/ml; DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml
pka: 4.74±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10007912
Product name: 20-carboxy Arachidonic Acid
Purity: >98%
Packaging: 25μg
Price: $224
Updated: 2024/03/01

Cayman Chemical

Product number: 10007912
Product name: 20-carboxy Arachidonic Acid
Purity: >98%
Packaging: 50μg
Price: $424
Updated: 2024/03/01

Cayman Chemical

Product number: 10007912
Product name: 20-carboxy Arachidonic Acid
Purity: >98%
Packaging: 100μg
Price: $800
Updated: 2024/03/01

TRC

Product number: A765063
Product name: 20-CarboxyArachidonicAcid
Packaging: 10mg
Price: $1890
Updated: 2021/12/16

Usbiological

Product number: 421299
Product name: 20-carboxy Arachidonic Acid
Packaging: 25μg
Price: $516
Updated: 2021/12/16

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20-carboxyarachidonic acid Chemical Properties,Usage,Production

Description

20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (K_d = 0.87 ± 0.12 μM) and PPARγ (K_d = 1.7 ± 0.5 μM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.

Uses

20-carboxy Arachidonic Acid is a PPARα and PPARγ activator.

Definition

ChEBI: An alpha,omega-dicarboxylic acid that is (5Z,8Z,11Z,14Z)-icosatetraene in which the two methyl groups are replaced by carboxy groups.

References

[1] XIANG FANG . 20-Carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors α and γ[J]. Prostaglandins & other lipid mediators, 2007, 82 1: Pages 175-184. DOI: 10.1016/j.prostaglandins.2006.05.002

20-carboxyarachidonic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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20-carboxyarachidonic acid Suppliers

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79551-84-1, 20-carboxyarachidonic acidRelated Search:

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5,8,11,14-Eicosatetraenedioic acid, (5Z,8Z,11Z,14Z)-

79551-84-1