DHP 218

Product Name: DHP 218
CAS No.: 102097-78-9
Chemical Name: DHP 218
Synonyms: PAK9;PAK 9;PAK-9;DHP 218;2-[1,4-Dihydro-2,6-dimethyl-3-(methoxycarbonyl)-4-(2-nitrophenyl)pyridin-5-yl]-1,3,2-dioxaphosphorinane 2-oxide
CBNumber: CB01389524
Formula Weight: 0
MOL File: 102097-78-9.mol

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Hazard and Precautionary Statements (GHS)

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DHP 218 Chemical Properties,Usage,Production

Description

DHP-218, also known as PAK-9, is a calcium channel antagonist potentially for the treatment of hypertension and myocardia ischemia. Calcium-induced contraction of the rat aorta in high K+ solution was inhibited by DHP-218 with the pA2 value of 9.11. The IC50 value for the inhibitory effects of this compound in high K+-induced and phenylephrine-induced contraction was 6.3 nmol/l and 66 nmol/l, respectively.

Uses

DHP-218 is a vasodilatory calcium antagonist with pronounced and long-lasting antihypertensive effects [1].

References

[1] Y Kimura, et al. Antihypertensive effects of a new dihydropyridine calcium antagonist. Arzneimittelforschung. 1986 Sep;36(9):1329-35. PMID:3790182

DHP 218 Preparation Products And Raw materials

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DHP 218 Suppliers

China 2 South Korea 1 United States 3 Global 6

TargetMol Chemicals Inc.

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102097-78-9, DHP 218Related Search:

DHP 218

2-[1,4-Dihydro-2,6-dimethyl-3-(methoxycarbonyl)-4-(2-nitrophenyl)pyridin-5-yl]-1,3,2-dioxaphosphorinane 2-oxide

PAK 9

PAK9

PAK-9

102097-78-9