2-(2-bromopyridin-3-yl)acetonitrile
- Product Name
- 2-(2-bromopyridin-3-yl)acetonitrile
- CAS No.
- 1211523-71-5
- Chemical Name
- 2-(2-bromopyridin-3-yl)acetonitrile
- Synonyms
- 3-Pyridineacetonitrile, 2-bromo-;2-(2-bromo-3-pyridyl)acetonitrile;2-(2-bromopyridin-3-yl)acetonitrile
- CBNumber
- CB01556830
- Molecular Formula
- C7H5BrN2
- Formula Weight
- 197.03
- MOL File
- 1211523-71-5.mol
2-(2-bromopyridin-3-yl)acetonitrile Property
- Boiling point:
- 323.3±27.0 °C(Predicted)
- Density
- 1.575±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -0.27±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5899AQ
- Product name
- 2-(2-bromopyridin-3-yl)acetonitrile
- Packaging
- 250mg
- Price
- $390.8
- Updated
- 2021/12/16
- Product number
- HCH0050390
- Product name
- 2-(2-BROMOPYRIDIN-3-YL)ACETONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1189.65
- Updated
- 2021/12/16
- Product number
- CM175154
- Product name
- 2-(2-bromopyridin-3-yl)acetonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $509
- Updated
- 2021/12/16
- Product number
- CD11330784
- Product name
- 2-(2-Bromopyridin-3-yl)acetonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $539
- Updated
- 2021/12/16
- Product number
- A100660
- Product name
- 2-(2-Bromopyridin-3-yl)acetonitrile
- Purity
- 95%
- Packaging
- 100mg
- Price
- $72
- Updated
- 2021/12/16
2-(2-bromopyridin-3-yl)acetonitrile Chemical Properties,Usage,Production
Synthesis
5697-44-9
128071-75-0
1211523-71-5
GENERAL STEPS: A 1,2-dimethoxyethane solution (20 mL) of p-toluenesulfonylacetonitrile (5.08 g, 26.02 mmol) was added slowly and dropwise to a suspension of potassium tert-butoxide (t-BuOK, 5.92 g, 52.76 mmol) in 1,2-dimethoxyethane (50 mL) at -60 °C. Maintaining the temperature at -60 °C, a 1,2-dimethoxyethane solution (20 mL) of 2-bromo-3-pyridinecarboxaldehyde (4.81 g, 25.86 mmol) was added dropwise to the above reaction mixture. After the reaction mixture was stirred at -60 °C for 1 h, methanol (MeOH, 50 mL) was added, followed by slow warming of the reaction system to room temperature and continued stirring for 1 h. The reaction mixture was then heated to room temperature and stirring was continued for 1 h. The reaction mixture was then heated to a temperature of 0.5 °C. Next, the reaction mixture was heated to 85 °C and kept for 1 hour. After completion of the reaction, it was cooled to room temperature and the volatile solvent was removed under reduced pressure. The residue was diluted with saturated brine (200 mL) and extracted with ethyl acetate (EA, 3 x 150 mL). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent of ethyl acetate:hexane (1:10, v/v) to afford the target product 2-(2-bromopyridin-3-yl)acetonitrile (2.21 g). Mass spectrometry (MS) analysis showed m/z 197 ([M+H]+).
References
[1] Patent: WO2018/172984, 2018, A1. Location in patent: Page/Page column 67
2-(2-bromopyridin-3-yl)acetonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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