Recombinant Human Vascular Endothelial Growth Factor receptor-2
Description Source Background- Product Name
- Recombinant Human Vascular Endothelial Growth Factor receptor-2
- Chemical Name
- Recombinant Human Vascular Endothelial Growth Factor receptor-2
- Synonyms
- Ly73;FLK1;Quek1;VEGFR;VEGFR2;VEGFR2 human;fetal liver kinase 1;KDR (789-end), active, GST tagged human;Anti-KDR (AB2) antibody produced in rabbit;Anti-KDR (AB1) antibody produced in rabbit
- CBNumber
- CB01562648
- Formula Weight
- 0
- MOL File
- Mol file
Recombinant Human Vascular Endothelial Growth Factor receptor-2 Property
- storage temp.
- -70°C
- form
- buffered aqueous glycerol solution
- biological source
- rabbit
N-Bromosuccinimide Price
- Product number
- SAB2900239
- Product name
- Anti-KDR (AB2) antibody produced in rabbit
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 50μG
- Price
- $544
- Updated
- 2025/07/31
- Product number
- SAB2900238
- Product name
- Anti-KDR (AB1) antibody produced in rabbit
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 50μg
- Price
- $544
- Updated
- 2025/07/31
- Product number
- K2643
- Product name
- KDR (789-end), active, GST tagged human
- Purity
- PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
- Packaging
- 10μg
- Price
- $521
- Updated
- 2024/03/01
- Product number
- 359634
- Product name
- VEGFR-2
- Packaging
- 48Tests
- Price
- $588
- Updated
- 2021/12/16
- Product number
- BITP1430
- Product name
- RecombinantHumanVascularEndothelialGrowthFactorreceptor-2
- Packaging
- 2μg
- Price
- $80
- Updated
- 2021/12/16
Recombinant Human Vascular Endothelial Growth Factor receptor-2 Chemical Properties,Usage,Production
Biological Activity
Vascular endothelial growth factor receptor 2 (VEGFR2) and its ligand VEGF play a vital role in angiogenesis and inflammation. It also facilitates autocrine stimulation of VEGF. VEGFR2 is implicated in progression of various types of cancers such as gliomas, malignant peripheral nerve sheath tumors, triple-negative breast cancer (TNBC) and gastrointestinal stromal tumors (GISTs).
Description
Soluble VEGFR-2 Human Recombinant produced in baculovirus is monomeric, glycosylated, polypeptide having a molecular mass of 116 kDa. The soluble receptor protein contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding.
The sKDR is purified by proprietary chromatographic techniques.
Source
Insect Cells
Background
Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation.
Differential splicing of the flt-1 gene leads to the formation of a secreted, soluble variant of VEGFR-1 (sVEGFR-1). No naturally occuring, secreted forms of VEGFR-2 have so far been reported. The binding of VEGF165 to VEGFR-2 is dependent on heparin.
Recombinant Human Vascular Endothelial Growth Factor receptor-2 Preparation Products And Raw materials
Raw materials
Preparation Products
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