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N-P-TOSYLGLYCINE

Product Name
N-P-TOSYLGLYCINE
CAS No.
1080-44-0
Chemical Name
N-P-TOSYLGLYCINE
Synonyms
Tos-Gly;TOS-GLY-OH;AURORA 963;N-TOS-Gly-OH;N-TOSYLGLYCINE;N-4-tosylglycine;N-P-TOSYLGLYCINE;N-p-Tosylglycine 97%;Tosylaminoacetic acid;OTAVA-BB BB0123400526
CBNumber
CB0160643
Molecular Formula
C9H11NO4S
Formula Weight
229.25
MOL File
1080-44-0.mol
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N-P-TOSYLGLYCINE Property

Melting point:
147-149 °C (lit.)
Boiling point:
430.0±55.0 °C(Predicted)
Density 
1.369±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.41±0.10(Predicted)
color 
White
Major Application
peptide synthesis
InChI
1S/C9H11NO4S/c1-7-2-4-8(5-3-7)15(13,14)10-6-9(11)12/h2-5,10H,6H2,1H3,(H,11,12)
InChIKey
VDKFCCZUCXYILI-UHFFFAOYSA-N
SMILES
Cc1ccc(cc1)S(=O)(=O)NCC(O)=O
CAS DataBase Reference
1080-44-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
2935.90.9500
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
403458
Product name
N-p-Tosylglycine
Purity
97%
Packaging
1g
Price
$31
Updated
2023/06/20
TCI Chemical
Product number
T2803
Product name
N-(p-Toluenesulfonyl)glycine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
T2803
Product name
N-(p-Toluenesulfonyl)glycine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$88
Updated
2025/07/31
TRC
Product number
T631720
Product name
N-Tosylglycine
Packaging
5g
Price
$95
Updated
2021/12/16
Chem-Impex
Product number
16453
Product name
(4-Methylphenylsulfonylamino)aceticacid,≥98%(HPLC)
Purity
≥98%(HPLC)
Packaging
5G
Price
$23.3
Updated
2021/12/16
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N-P-TOSYLGLYCINE Chemical Properties,Usage,Production

Uses

N-Tosylglycine is a sulfonamide derivative used to synthesize metal complexes which potentially displays antibacterial activity.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

98-59-9

56-40-6

1080-44-0

Sodium carbonate (Na2CO3, 1.590 g, 15 mmol) was added to a solution of glycine (12.5 mmol) in water (15 mL) under continuous stirring until completely dissolved. The solution was cooled to -5°C and p-toluenesulfonyl chloride (15 mmol) was added in four batches over 1 hour. The reaction mixture was continued to be stirred at room temperature for about 4 h. The progress of the reaction was monitored using thin layer chromatography (TLC, unfolding agent was MeOH/DCM, 1:9). Upon completion of the reaction, the mixture was acidified with 20% aqueous hydrochloric acid to pH 2. The crystals were collected by diafiltration and washed with pH 2.2 buffer. The pure product 2-(4-methylphenylsulfonamido)acetic acid was dried in a desiccator. The yield was 99.34% (2.8410 g) and the melting point was 88.4-88.6°C. FTIR (KBr, cm-1 ): 3448 (O-H, COOH), 3277 (N-H), 2957 (C-H, aliphatic), 1730 (C=O), 1598, 1440 (C=C), 1354, 1321 (2S=O). 1185 (SO2-NH), 1111, 1094 (C-N, C-O).1H NMR (DMSO-d6) δ: 7.90-7.88 (t, J=6.3 Hz, 1H, NH), 7.65-7.63 (d, J=8.6 Hz, 2H, ArH), 7.34-7.33 (d, J=8.05 Hz, 2H, ArH ), 3.52-3.51 (d, J=5.7 Hz, 2H, CH2), 2.34 (s, 3H, CH3).13C NMR (DMSO-d6) δ: 170.7 (C=O), 143.1, 138.4, 130.0, 127.1 (aryl carbons), 44.3 (CH2), 21.5 (CH3).HRMS-ESI (m/z): 228.0412 ([M-H]-, calculated value: 228.0408).

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 135, p. 349 - 369
[2] PLoS ONE, 2018, vol. 13, # 1,
[3] Journal of the American Chemical Society, 2018, vol. 140, # 17, p. 5834 - 5841
[4] Journal of Molecular Catalysis A: Chemical, 2011, vol. 351, p. 41 - 45
[5] Organic and Biomolecular Chemistry, 2018, vol. 16, # 31, p. 5618 - 5625

N-P-TOSYLGLYCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-P-TOSYLGLYCINE Suppliers

Austria 1 China 162 Europe 1 Germany 2 India 4 Japan 4 Switzerland 1 Ukraine 2 United Kingdom 2 United States 17 Global 196
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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021-67121386
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Jia Xing Isenchem Co.,Ltd
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021-54306202 13764082696
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View Lastest Price from N-P-TOSYLGLYCINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
N-P-TOSYLGLYCINE 1080-44-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-(p-Toluenesulfonyl)glycine 1080-44-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
N-P-TOSYLGLYCINE 1080-44-0
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-07-26

1080-44-0, N-P-TOSYLGLYCINERelated Search:

TOS-PRO-OH N-(p-Tolylsulphonyl)-L-glutamic acid TOS-LYS(BOC)-OH N-(P-TOLUENESULFONYL)-L-PHENYLALANINE TOS-ARG-OH N-P-TOSYLGLYCINE TOS-ARG-OME HCL TOS-GLU-OH TOS-GLY-OSU Tosyl-S-Benzyl-L-cysteine TOS-MET-OH N-[P-TOLUENESULFONYL]-L-LYSINE METHYL ESTER HYDROCHLORIDE 2-([(4-METHYLPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID 4-METHYL-2-(TOLUENE-4-SULFONYLAMINO)-PENTANOIC ACID NEPSILON-CARBOBENZOXY-NALPHA-TOSYL-L-LYSINE 3-METHYL-2-(TOLUENE-4-SULFONYLAMINO)-BUTYRIC ACID 3-HYDROXY-2-(TOLUENE-4-SULFONYLAMINO)-PROPIONIC ACID 3-AMINO-2-(TOLUENE-4-SULFONYLAMINO)-PROPIONIC ACID

  • (4-METHYLPHENYLSULFONYLAMINO)ACETIC ACID
  • N-4-tosylglycine
  • N-TOS-Gly-OH
  • N-(4-Toluenesulfonyl)-glycine
  • N-(4-TOLUENESULFONYL)-GLYCINE N-P-TOSYLGLYCINE
  • (Toluene-4-sulfonylamino)-acetic acid
  • P-toluenesulfonate glycine
  • Tosylaminoacetic acid
  • 2-[(4-methylphenyl)sulfonylamino]acetic acid
  • 2-[(4-methylphenyl)sulfonylamino]ethanoic acid
  • 2-[(4-Methylbenzene)sulfonaMido]acetic acid
  • N-Tosylglycine Tos-Gly-OH
  • 2-(4-MethylphenylsulfonaMido)acetic acid
  • Tos-Gly
  • N-p-Tosylglycine 97%
  • (p-Toluenesulfonamido)acetic acid
  • Glycine, N-((4-methylphenyl)sulfonyl)-
  • Glycine, N-[(4-methylphenyl)sulfonyl]-
  • N-p-toluenesulfonyl-dl-glycine
  • N-TOSYLGLYCINE (GLYCINE-13C2
  • N-((4-METHYLPHENYL)SULFONYL)GLYCINE
  • P-TOLUENESULFONYLGLYCINE
  • OTAVA-BB BB0123400526
  • N-TOSYLGLYCINE
  • N-(P-TOLUENE SULFONYL) GLYCINE
  • N-P-TOSYLGLYCINE
  • TOS-GLY-OH
  • AURORA 963
  • <i>N</i>-(<i>p</i>-Toluenesulfonyl)glycine
  • N-P-TOSYLGLYCINE USP/EP/BP
  • <i>N</i>-<i>p</i>-Tosylglycine
  • 1080-44-0
  • CH3C6H4SO2NHCH2CO2H
  • Amino Acid Derivatives
  • Peptide Synthesis
  • Specialty Synthesis
  • Glycine [Gly, G]