N-P-TOSYLGLYCINE
- Product Name
- N-P-TOSYLGLYCINE
- CAS No.
- 1080-44-0
- Chemical Name
- N-P-TOSYLGLYCINE
- Synonyms
- Tos-Gly;TOS-GLY-OH;AURORA 963;N-TOS-Gly-OH;N-TOSYLGLYCINE;N-4-tosylglycine;N-P-TOSYLGLYCINE;N-p-Tosylglycine 97%;Tosylaminoacetic acid;OTAVA-BB BB0123400526
- CBNumber
- CB0160643
- Molecular Formula
- C9H11NO4S
- Formula Weight
- 229.25
- MOL File
- 1080-44-0.mol
N-P-TOSYLGLYCINE Property
- Melting point:
- 147-149 °C (lit.)
- Boiling point:
- 430.0±55.0 °C(Predicted)
- Density
- 1.369±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.41±0.10(Predicted)
- color
- White
- CAS DataBase Reference
- 1080-44-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 403458
- Product name
- N-p-Tosylglycine
- Purity
- 97%
- Packaging
- 1g
- Price
- $31
- Updated
- 2023/06/20
- Product number
- T2803
- Product name
- N-(p-Toluenesulfonyl)glycine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- T2803
- Product name
- N-(p-Toluenesulfonyl)glycine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $88
- Updated
- 2025/07/31
- Product number
- T631720
- Product name
- N-Tosylglycine
- Packaging
- 5g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 16453
- Product name
- (4-Methylphenylsulfonylamino)aceticacid,≥98%(HPLC)
- Purity
- ≥98%(HPLC)
- Packaging
- 5G
- Price
- $23.3
- Updated
- 2021/12/16
N-P-TOSYLGLYCINE Chemical Properties,Usage,Production
Uses
N-Tosylglycine is a sulfonamide derivative used to synthesize metal complexes which potentially displays antibacterial activity.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
98-59-9
56-40-6
1080-44-0
Sodium carbonate (Na2CO3, 1.590 g, 15 mmol) was added to a solution of glycine (12.5 mmol) in water (15 mL) under continuous stirring until completely dissolved. The solution was cooled to -5°C and p-toluenesulfonyl chloride (15 mmol) was added in four batches over 1 hour. The reaction mixture was continued to be stirred at room temperature for about 4 h. The progress of the reaction was monitored using thin layer chromatography (TLC, unfolding agent was MeOH/DCM, 1:9). Upon completion of the reaction, the mixture was acidified with 20% aqueous hydrochloric acid to pH 2. The crystals were collected by diafiltration and washed with pH 2.2 buffer. The pure product 2-(4-methylphenylsulfonamido)acetic acid was dried in a desiccator. The yield was 99.34% (2.8410 g) and the melting point was 88.4-88.6°C. FTIR (KBr, cm-1 ): 3448 (O-H, COOH), 3277 (N-H), 2957 (C-H, aliphatic), 1730 (C=O), 1598, 1440 (C=C), 1354, 1321 (2S=O). 1185 (SO2-NH), 1111, 1094 (C-N, C-O).1H NMR (DMSO-d6) δ: 7.90-7.88 (t, J=6.3 Hz, 1H, NH), 7.65-7.63 (d, J=8.6 Hz, 2H, ArH), 7.34-7.33 (d, J=8.05 Hz, 2H, ArH ), 3.52-3.51 (d, J=5.7 Hz, 2H, CH2), 2.34 (s, 3H, CH3).13C NMR (DMSO-d6) δ: 170.7 (C=O), 143.1, 138.4, 130.0, 127.1 (aryl carbons), 44.3 (CH2), 21.5 (CH3).HRMS-ESI (m/z): 228.0412 ([M-H]-, calculated value: 228.0408).
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 135, p. 349 - 369
[2] PLoS ONE, 2018, vol. 13, # 1,
[3] Journal of the American Chemical Society, 2018, vol. 140, # 17, p. 5834 - 5841
[4] Journal of Molecular Catalysis A: Chemical, 2011, vol. 351, p. 41 - 45
[5] Organic and Biomolecular Chemistry, 2018, vol. 16, # 31, p. 5618 - 5625
N-P-TOSYLGLYCINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-P-TOSYLGLYCINE manufacturers
- Product
- N-P-TOSYLGLYCINE 1080-44-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- N-(p-Toluenesulfonyl)glycine 1080-44-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- N-P-TOSYLGLYCINE 1080-44-0
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-07-26