2-CHLORO-6-METHOXY-QUINOLINE
- Product Name
- 2-CHLORO-6-METHOXY-QUINOLINE
- CAS No.
- 13676-02-3
- Chemical Name
- 2-CHLORO-6-METHOXY-QUINOLINE
- Synonyms
- Einecs 237-162-9;2-CHLORO-6-METHOXY-QUINOLINE;6-METHOXY-2-CHLORO-QUINOLINE;Quinoline, 2-chloro-6-methoxy-;2-Chloro-6-methoxy-1-azanaphthalene
- CBNumber
- CB0162238
- Molecular Formula
- C10H8ClNO
- Formula Weight
- 193.63
- MOL File
- 13676-02-3.mol
2-CHLORO-6-METHOXY-QUINOLINE Property
- Melting point:
- 106-107℃
- Boiling point:
- 310.5±22.0 °C(Predicted)
- Density
- 1.267
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 0.37±0.43(Predicted)
- form
- solid
- Appearance
- White to yellow Solid
N-Bromosuccinimide Price
- Product number
- BBO000233
- Product name
- 2-Chloro-6-methoxyquinoline
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $286
- Updated
- 2025/07/31
- Product number
- C368593
- Product name
- 2-Chloro-6-methoxyquinoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C368593
- Product name
- 2-Chloro-6-methoxyquinoline
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 4H56-5-5P
- Product name
- 2-Chloro-6-methoxyquinoline
- Packaging
- 1g
- Price
- $288
- Updated
- 2021/12/16
- Product number
- OR307500
- Product name
- 2-Chloro-6-methoxyquinoline
- Packaging
- 1g
- Price
- $261
- Updated
- 2021/12/16
2-CHLORO-6-METHOXY-QUINOLINE Chemical Properties,Usage,Production
Synthesis
13676-00-1
13676-02-3
General procedure for the synthesis of 2-chloro-6-methoxyquinoline from 6-methoxyquinolin-2(1H)-one: 6-methoxyquinolin-2-ol (400 mg, 2.29 mmol) was dissolved in phosphorus trichloride (5.0 mL) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (50 mL) and the organic layer was washed sequentially with saturated sodium bicarbonate solution (30 mL × 2). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 10:1) to afford 2-chloro-6-methoxyquinoline (380 mg, 86% yield) as a white solid.1H NMR (CDCl3, 400 MHz): δ 7.92 (d, J = 8.4 Hz, 1H), 7.85 (d, J = 9.2 Hz, 1H), 7.32-7.25 ( m, 2H), 7.00 (d, J = 2.4 Hz, 1H), 3.86 (s, 3H).
References
[1] Patent: WO2012/48181, 2012, A1. Location in patent: Page/Page column 74
[2] Patent: WO2012/83165, 2012, A1. Location in patent: Page/Page column 91
[3] Ann. Inst. Pasteur, 1930, vol. 44, p. 719,736
2-CHLORO-6-METHOXY-QUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-6-METHOXY-QUINOLINE Suppliers
- Tel
- +1-2266000236
- sales@rdscientific.com
- Country
- Canada
- ProdList
- 1914
- Advantage
- 58
View Lastest Price from 2-CHLORO-6-METHOXY-QUINOLINE manufacturers
- Product
- 2-Chloro-6-methoxyquinoline 13676-02-3
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 2-chloro-6-methoxyquinoline 13676-02-3
- Price
- US $2800.00/g
- Min. Order
- 1g
- Purity
- 99 %
- Supply Ability
- 5000 Kg
- Release date
- 2025-06-26
- Product
- 2-CHLORO-6-METHOXY-QUINOLINE 13676-02-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23