18-HYDROXY-11-DEOXYCORTICOSTERONE

Product Name: 18-HYDROXY-11-DEOXYCORTICOSTERONE
CAS No.: 379-68-0
Chemical Name: 18-HYDROXY-11-DEOXYCORTICOSTERONE
Synonyms: 18-HYDROXY DOC;18-HYDROXYDEOXYCORTICOSTERONE;4-PREGNEN-18,21-DIOL-3,20-DIONE;4-PREGNENE-18,21-DIOL-3,20-DIONE;18-HYDROXY-11-DEOXYCORTICOSTERONE;11-DEOXY-18-HYDROXYCORTICOSTERONE;18,21-dihydroxypregn-4-ene-3,20-dione;18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE;Pregn-4-ene-3,20-dione, 18,21-dihydroxy-;18,20-EPOXY-20,21-DIHYDROXY-4-PREGNEN-3-ONE
CBNumber: CB0164085
Molecular Formula: C21H30O4
Formula Weight: 346.46
MOL File: 379-68-0.mol

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18-HYDROXY-11-DEOXYCORTICOSTERONE Property

Melting point:: 171-173 °C
storage temp.: 2-8°C
solubility: Chloroform (Slightly, Sonicated), Methanol (Slightly, Heated)
form: Solid
color: White to Off-White
LogP: 1.571 (est)

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Safety

Safety Statements: 22-24/25

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R200077
Product name: 18,20-EPOXY-20,21-DIHYDROXYPREGN-4-EN-3-ONE
Purity: AldrichCPR
Packaging: 1MG
Price: $134
Updated: 2023/06/20

Cayman Chemical

Product number: 10007851
Product name: 18-hydroxy-11-deoxy Corticosterone
Packaging: 1mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 10007851
Product name: 18-hydroxy-11-deoxy Corticosterone
Packaging: 500μg
Price: $75
Updated: 2021/12/16

TRC

Product number: D239680
Product name: 11-Deoxy-18-hydroxycorticosterone
Packaging: 1mg
Price: $235
Updated: 2021/12/16

AK Scientific

Product number: 3712CA
Product name: 18,21-Dihydroxypregn-4-ene-3,20-dione
Packaging: 1mg
Price: $293
Updated: 2021/12/16

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18-HYDROXY-11-DEOXYCORTICOSTERONE Chemical Properties,Usage,Production

Description

18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; ) as well as angiotensin II , which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; ) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone and can be converted to aldosterone by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.

Uses

11-Deoxy-18-hydroxycorticosterone is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.

Definition

ChEBI: 18-hydroxydeoxycorticosterone is a 21-hydroxy steroid, a 3-oxo-Delta(4) steroid, a 20-oxo steroid and a 18-hydroxy steroid.

Purification Methods

Recrystallise 18-hydroxy-11-deoxycorticosterone from Et2O/Me2CO to give crystals m 200-205o. When it is recrystallised from M2CO, it has m 191-195o. It has UV with max at 240nm. The 21-O-acetoxy-18-hydroxy derivative has m 158-159o (from Et2O/*C6H6), and the 21-O-acetoxy-18,20-epoxy derivative has m 149-154o (from Et2O). [Kahnt et al. Helv Chim Acta 38 1237 1955; Pappo J Am Chem Soc 81 1010 1959.]

18-HYDROXY-11-DEOXYCORTICOSTERONE Preparation Products And Raw materials

Raw materials

Preparation Products

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18-HYDROXY-11-DEOXYCORTICOSTERONE Suppliers

China 12 France 1 Germany 1 India 1 South Korea 1 Switzerland 1 United States 5 USA 1 Global 23

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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United States Biological

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379-68-0, 18-HYDROXY-11-DEOXYCORTICOSTERONERelated Search:

18-HYDROXYCORTICOSTERONE, [1,2-3H] D-ALDOSTERONE 18,21-DIACETATE 18-HYDROXYCORTICOSTERONE ALDOSTERONE, D-[1,2-3H(N)]- 18-HYDROXY-11-DEOXYCORTICOSTERONE 4-PREGNEN-11-BETA, 21-DIOL-3,18,20-TRIONE 21-GLUCOSIDURONATE ALDOSTERONE, D [1,2,6,7-3H(N)] 18-HYDROXY SUBSTANCE S D-ALDOSTERONE 21-ACETATE

11-DEOXY-18-HYDROXYCORTICOSTERONE

18-HYDROXY-11-DEOXYCORTICOSTERONE

18-HYDROXYDEOXYCORTICOSTERONE

18-HYDROXY DOC

18,20-EPOXY-20,21-DIHYDROXY-4-PREGNEN-3-ONE

18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE

4-PREGNENE-18,21-DIOL-3,20-DIONE

4-PREGNEN-18,21-DIOL-3,20-DIONE

18,21-dihydroxypregn-4-ene-3,20-dione

11-Deoxy-18-hydroxycorticosterone, 18,20-Epoxy-20,21-dihydroxy-4-pregnen-3-one, 18,21-Dihydroxy-4-pregnene-3,20-dione

18-Hydroxy-21-hydroxypregna-4-ene-3,20-dione

(8R,9S,10R,13R,14S,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

(8R,9S,10R,13R,14S,17S)-17-(2-hydroxyethanoyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

(8R,9S,10R,13R,14S,17S)-17-glycoloyl-10-methyl-13-methylol-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Pregn-4-ene-3,20-dione, 18,21-dihydroxy-

379-68-0