1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE

Product Name: 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE
CAS No.: 287471-30-1
Chemical Name: 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE
Synonyms: Terbinafine Impurity 45;Terbinafine Impurity 22;1-Chloro-6,6-dimethyl-2-hepten-4-yne;2-HEPTEN-4-YNE,1-CHLORO-6,6-DIMETHYL;1-Chloro-6,6-dimethyl-2-hepten-4-ino;(E)-1-chloro-6,6-diMethylhept-2-en-4-yne;(2E)-1-chloro-6,6-dimethylhept-2-en-4-yne;1-CHLORO-6,6-DIMETHYL-2-ENE-4-YNE-HEPTANE;2-HEPTEN-4-YNE, 1-CHLORO-6,6-DIMETHYL-, (2E)-
CBNumber: CB0198486
Molecular Formula: C9H13Cl
Formula Weight: 156.65
MOL File: 287471-30-1.mol

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1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Property

Boiling point:: 207.5±23.0 °C(Predicted)
Density: 0.946±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere, 2-8°C
InChI: InChI=1S/C9H13Cl/c1-9(2,3)7-5-4-6-8-10/h4,6H,8H2,1-3H3/b6-4+
InChIKey: ZIXABMZBMHDFEZ-GQCTYLIASA-N
SMILES: C(Cl)/C=C/C#CC(C)(C)C
CAS DataBase Reference: 287471-30-1(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0036879
Product name: (2E)-1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE
Purity: 95.00%
Packaging: 25G
Price: $1404.36
Updated: 2021/12/16

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1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Chemical Properties,Usage,Production

Description

1-Chloro-6,6-dimethyl-2-hepten-4-yne is the allylamine antifungal agents terbinafine intermediate.1-Chloro-6,6-dimethyl-2-hepten-4-yne choose to inhibit COX-fungal squalene, so that reduction of membrane ergosterol, thus inhibiting the growth of fungi play an inhibitory role; right ergosterol synthesis of precursors and no inhibitory effect on other stages.

Uses

1-Chloro-6,6-dimethyl-2-heptene-4-yne is a hydrocarbon derivative and can be used as a pharmaceutical intermediate.

Application

1-Chloro-6,6-dimethyl-2-hepten-4-yne is a chlorinating agent that has been used to minimise hydrochloric acid by converting it to chloride. It is also used in the chlorination of magnesium and other metals. 1-Chloro-6,6-dimethyl-2-hepten-4-yne has been shown to be an effective antifungal agent against dermatophytes such as Trichophyton rubrum and Microsporum canis. The compound is toxic to humans and animals because it produces acrolein and terbinafine during chlorination. It also produces hydrochloric acid as a by-product of chlorination.

Synthesis

1-Chloro-6,6-dimethyl-2-hepten-4-yne mainly due to keratin aggregation produce squalene, was squalene cyclooxygenase inhibition, squalene in the cells of a large number gathered in the form of lipid droplets penetrate fungal cell membrane, destruction of the membrane lipid composition, resulting in fungal death. A typical procedure for preparing of 1-chloro-6,6-dimethyl-2-hepten-4-yne using boron trichloride is as follows: Compound 1 (53 g, 0.38 mol) in 2800 mL of n-hexane was cooled to 10??15??. Boron trichloride (1 M in hexane, 480 mL, 0.48 mol) was added to the mixture at 15??20?? over a 10 min period. After 10 min of stirring at 20??, the mixture was quenched with 1000 mL of water and stirred for 10 min. The separated organic phase was washed with 20% NaCl, dried (MgSO4), and evaporated to afford the title compound 2 (57.1 g, 95%) in 9:1 E:Z ratio.

1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE Suppliers

China 142 Europe 1 France 1 Germany 2 India 1 South Korea 1 The Netherlands 1 Ukraine 2 United Kingdom 2 United States 15 Global 168

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768836
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The future of Shanghai Industrial Co., Ltd.

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Bide Pharmatech Ltd.

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Wuxi Zhongkun Biochemical Technology Co., Ltd.

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Wuhan Dahua Pharmaceutical Co., Ltd.

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Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.

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Chengdu RunZeBenTu Chemical Co., Ltd

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Chengdu DingDang Pharmaceutical Co., Ltd.

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View Lastest Price from 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE manufacturers

shandong perfect biotechnology co.ltd

Product: 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 287471-30-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99% HPLC
Supply Ability: 100 kgs
Release date: 2023-07-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 287471-30-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 287471-30-1
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-17

287471-30-1, 1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNERelated Search:

Terbinafine Hydrochloride 6,6-Dimethyl-1-hepten-4-yn-3-ol 1-CHLORO-6,6-DIMETHYL-2-HEPTENE-4-YNE 3,3-Dimethyl-1-butyne N-Methyl-2-naphthaMide 1-Methyl-aminomethyl naphthalene (Z)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)hept-2-en-4-yn-1-aMine 1-Chloro-6,6-dimethyl-2-heptene-4-yne (E)-N,6,6-triMethyl-N-(naphthalen-2-ylMethyl)hept-2-en-4-yn-1-aMine Terbinafine methyl-(naphthalen-2-ylmethyl)azanium N-[(2E)-6,6-DiMethyl-2-hepten-4-yn-1-yl]-N-Methyl-2-naphthaleneMethanaMine Hydrochloride cis-Terbinafine Hydrochloride (E)-1-Bromo-6,6-dimethyl-2-hepten-4-yne Chlorotrimethylsilane chlorempenthrin

2-HEPTEN-4-YNE, 1-CHLORO-6,6-DIMETHYL-, (2E)-

1-CHLORO-6,6-DIMETHYL-2-ENE-4-YNE-HEPTANE

1-Chloro-6,6-dimethyl-2-hepten-4-ino

2-HEPTEN-4-YNE,1-CHLORO-6,6-DIMETHYL

1-Chloro-6,6-dimethyl-2-hepten-4-yne

(E)-1-chloro-6,6-diMethylhept-2-en-4-yne

(2E)-1-chloro-6,6-dimethylhept-2-en-4-yne

Terbinafine Impurity 22

Terbinafine Impurity 45

287471-30-1

Chemical intermediate for Terbinafine