5-nitro-4-bromoisoquinoline

Product Name: 5-nitro-4-bromoisoquinoline
CAS No.: 58142-46-4
Chemical Name: 5-nitro-4-bromoisoquinoline
Synonyms: 5-nitro-4-bromoisoquinoline;Isoquinoline, 4-bromo-5-nitro-;Boronicacid,B-1H-benzimidazol-5-yl-
CBNumber: CB01999329
Molecular Formula: C9H5BrN2O2
Formula Weight: 253.05
MOL File: 58142-46-4.mol

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5-nitro-4-bromoisoquinoline Property

Melting point:: 172-174 °C(Solv: methanol (67-56-1))
Boiling point:: 379.9±27.0 °C(Predicted)
Density: 1.747±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 1.49±0.14(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0044412
Product name: 4-BROMO-5-NITROISOQUINOLINE
Purity: 95.00%
Packaging: 1G
Price: $1052.67
Updated: 2021/12/16

AK Scientific

Product number: Y5811
Product name: 4-Bromo-5-nitroisoquinoline
Packaging: 5g
Price: $1154
Updated: 2021/12/16

Matrix Scientific

Product number: 131811
Product name: 4-Bromo-5-nitroisoquinoline
Purity: 97%
Packaging: 5g
Price: $1980
Updated: 2021/12/16

Matrix Scientific

Product number: 131811
Product name: 4-Bromo-5-nitroisoquinoline
Purity: 97%
Packaging: 25g
Price: $5940
Updated: 2021/12/16

Ambeed

Product number: A102007
Product name: 4-Bromo-5-nitroisoquinoline
Purity: 97%
Packaging: 100mg
Price: $58
Updated: 2021/12/16

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5-nitro-4-bromoisoquinoline Chemical Properties,Usage,Production

Synthesis

1532-97-4

58142-46-4

General procedure for the synthesis of 4-bromo-5-nitroisoquinoline (11) from 4-bromoisoquinoline: potassium nitrate (5.34 g, 0.052 mol) was slowly added to 20 mL of concentrated sulfuric acid and dissolved by careful heating. The resulting solution was added dropwise to a solution of 4-bromoisoquinoline (10 g, 0.048 mol) dissolved in 40 mL of the same acid at 0 °C. After removing the cooling bath, the reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was poured into crushed ice (400 g) and adjusted to alkaline with ammonium hydroxide. The resulting yellow precipitate was collected by filtration and the filtrate was extracted with ether (3 x 500 mL), dried over anhydrous sodium sulfate and concentrated to give a yellow solid. This solid was combined with the initial precipitate and recrystallized from methanol to give 12.1 g (89% yield) of 4-bromo-5-nitroisoquinoline (11) as light yellow crystals.

References

[1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 6, p. 1403 - 1412
[2] Patent: WO2006/12640, 2006, A2. Location in patent: Page/Page column 43
[3] Patent: US2007/155720, 2007, A1. Location in patent: Page/Page column 20
[4] Patent: US2002/132827, 2002, A1
[5] Patent: US6413977, 2002, B1

5-nitro-4-bromoisoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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58142-46-4, 5-nitro-4-bromoisoquinolineRelated Search:

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Boronicacid,B-1H-benzimidazol-5-yl-

58142-46-4