ChemicalBook > CAS DataBase List > N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE

N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE

Product Name
N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE
CAS No.
189060-98-8
Chemical Name
N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE
Synonyms
N B2904;Ngb-2904;Ngb 2904;NGB2904 HCl;NGB 2904 HYDROCHLORIDE;NGB 2904, 10 mM in DMSO;N-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyl)-3-fluorenylcarboxamide;N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide;N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-9H-fluorene-2-carboxamide;9H-Fluorene-2-carboxamide, N-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyl)-
CBNumber
CB02453431
Molecular Formula
C28H29Cl2N3O
Formula Weight
494.46
MOL File
189060-98-8.mol
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N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE Property

Boiling point:
691.0±55.0 °C(Predicted)
Density 
1.264±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at +4°C
solubility 
DMSO: 25 mM,Ethanol: 5 mM
pka
14.70±0.20(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2635
Product name
NGB2904
Purity
≥98%(HPLC)
Packaging
10
Price
$217
Updated
2021/12/16
Tocris
Product number
2635
Product name
NGB2904
Purity
≥98%(HPLC)
Packaging
50
Price
$872
Updated
2021/12/16
TRC
Product number
N393505
Product name
NGB2904
Packaging
10mg
Price
$160
Updated
2021/12/16
Usbiological
Product number
255979
Product name
NGB 2904
Packaging
10mg
Price
$466
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0360490
Product name
N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$501.96
Updated
2021/12/16
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N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

NGB 2904 is a highly-selective D3DR antagonist.

Biological Activity

Potent and selective dopamine D 3 receptor antagonist (K i values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D 3 , D 2 , 5-HT 2 , α 1 , D 4 , D 1 and D 5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC 50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.

in vivo

NGB 2904 (26 μg/kg; a single s.c.) enhances amphetamine (26 mg/kg)-stimulated locomotion in wild-type mice[3].
NGB 2904 (0.026 μg-1 mg/kg; a single s.c. or once daily for 7 d) stimulates spontaneous locomotion in wild-type mice[3].

IC 50

D3 Receptor: 1.4 nM (Ki)

N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE Suppliers

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189060-98-8, N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDERelated Search:

2-FLUORENECARBOXALDEHYDE 1-(2,3-Dichlorophenyl)piperazine hydrochloride N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE

  • 9H-Fluorene-2-carboxamide, N-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyl)-
  • N-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyl)-3-fluorenylcarboxamide
  • Ngb 2904
  • Ngb-2904
  • N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide
  • N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE
  • NGB 2904 HYDROCHLORIDE
  • N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-9H-fluorene-2-carboxamide
  • NGB2904 HCl
  • addiction,NGB 2904,orally,active,cocaine,Dopamine Receptor,dopamine,inhibit,Inhibitor,selective
  • N B2904
  • NGB 2904, 10 mM in DMSO
  • 189060-98-8
  • 189060-98-3
  • C28H30Cl3N3O
  • C28H29Cl2N3OHCl
  • C28H29Cl2N3O