3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
- Product Name
- 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
- CAS No.
- 4922-68-3
- Chemical Name
- 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
- Synonyms
- Ponatinib Impurity 9;s-Triazolo[4,3-a]pyridine, 3-bromo-;3-bromo-[1,2,4]triazolo[4,3-a]pyridine;1,2,4-TRIAZOLO[4,3-A]PYRIDINE, 3-BROMO-
- CBNumber
- CB02456245
- Molecular Formula
- C6H4BrN3
- Formula Weight
- 198.02
- MOL File
- 4922-68-3.mol
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Property
- Melting point:
- 165-167 °C
- Density
- 1.89±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.97±0.50(Predicted)
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C6H4BrN3/c7-6-9-8-5-3-1-2-4-10(5)6/h1-4H
- InChIKey
- BOKHADJFZUWNSH-UHFFFAOYSA-N
- SMILES
- C12=NN=C(Br)N1C=CC=C2
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H310Fatal in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P262Do not get in eyes, on skin, or on clothing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B688425
- Product name
- 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- B688425
- Product name
- 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
- Packaging
- 1g
- Price
- $935
- Updated
- 2021/12/16
- Product number
- 074636
- Product name
- 3-Bromo[1,2,4]triazolo[4,3-a]pyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $899
- Updated
- 2021/12/16
- Product number
- HCH0143576
- Product name
- 3-BROMO[1,2,4]TRIAZOLO[4,3-ALPHA]PYRIDINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $1034.88
- Updated
- 2021/12/16
- Product number
- W6495
- Product name
- 3-Bromo[1,2,4]triazolo[4,3-a]pyridine
- Packaging
- 25g
- Price
- $1400
- Updated
- 2021/12/16
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Chemical Properties,Usage,Production
Uses
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine is an intermediate used to prepare bi-aryl amines as mGluR5 modulators for treating gastrointestinal, urinary tract, and nervous system disorders.
Synthesis
274-80-6
4922-68-3
General procedure for the synthesis of 3-bromo-[1,2,4]triazolo[4,3-a]pyridine from [1,2,4]triazolo[4,3-a]pyridine: [1,2,4]triazolo[4,3-a]pyridine (1.26 g) and N-bromosuccinimide (NBS, 1.98 g) were dissolved in chloroform, and the reaction was carried out at reflux for 5 h followed by a 14-h stand at room temperature. Upon completion of the reaction, saturated aqueous potassium carbonate (200 mL) and potassium hydroxide (20 g) were added to the mixture, and the organic layer was separated after sufficient shaking. The aqueous layer was extracted twice with dichloromethane (DCM). All organic layers were combined and dried over anhydrous sodium sulfate (Na2SO4) followed by evaporation of the solvent under vacuum to afford the target product 3-bromo-[1,2,4]triazolo[4,3-a]pyridine in 60% yield.
References
[1] Patent: EP2743266, 2014, A2. Location in patent: Page/Page column
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Suppliers
- Tel
- 21-57721279
- Fax
- QQ：14057904
- sales@shydchem.com.cn
- Country
- China
- ProdList
- 998
- Advantage
- 56
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- +86-021-58975553
- Fax
- +86-021-58975554
- sales@cooperpharm.com
- Country
- China
- ProdList
- 1210
- Advantage
- 56
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 13052276172
- Fax
- 13052276172
- product@yuyuanpharm.com
- Country
- China
- ProdList
- 493
- Advantage
- 55
View Lastest Price from 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine manufacturers
- Product
- 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine 4922-68-3
- Price
- US $1.00-2.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20000KG
- Release date
- 2024-08-09
- Product
- 1,2,4-TRIAZOLO[4,3-A]PYRIDINE, 3-BROMO- 4922-68-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-03