tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

Product Name: tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
CAS No.: 1181816-12-5
Chemical Name: tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
Synonyms: tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate;2-Boc-6-oxo-2-azaspiro[3....;6-oxo-2-azaspiro[3.3]hept...;2-Boc-6-oxo-2-azaspiro[3.3]heptane;6-oxo-2-azaspiro[3.3]heptane-2-carboxyL;tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-ca;ert-Butyl6-oxo-2-azaspiro[3.3]heptane-2-carboxylate;Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate;tert-Butyl 7-oxo-2-azaspiro[3.4]octane-2-carboxylate;tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
CBNumber: CB02470890
Molecular Formula: C11H17NO3
Formula Weight: 211.26
MOL File: 1181816-12-5.mol

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tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Property

Melting point:: 114.5-116 °C
Boiling point:: 314.7±42.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -0.93±0.20(Predicted)
form: solid
color: Pale yellow
InChI: InChI=1S/C11H17NO3/c1-10(2,3)15-9(14)12-6-11(7-12)4-8(13)5-11/h4-7H2,1-3H3
InChIKey: HQHRAGXKFOTSQE-UHFFFAOYSA-N
SMILES: C1C2(CC(=O)C2)CN1C(OC(C)(C)C)=O
CAS DataBase Reference: 1181816-12-5

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D6207
Product name: tert-Butyl 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate
Purity: min. 98.0 %
Packaging: 1G
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: D6207
Product name: tert-Butyl 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate
Purity: min. 98.0 %
Packaging: 5G
Price: $192
Updated: 2025/07/31

TRC

Product number: B809410
Product name: tert-Butyl6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: B809410
Product name: tert-Butyl6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate
Packaging: 500mg
Price: $165
Updated: 2021/12/16

TRC

Product number: B809410
Product name: tert-Butyl6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate
Packaging: 2.5g
Price: $605
Updated: 2021/12/16

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tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Chemical Properties,Usage,Production

Uses

tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate is a reagent used for the preparation of γ-butyrolactone derivative via Baeyer-Villiger monooxygenase (BVMO)-catalyzed oxidation.

Synthesis

A solution of crude tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate (1.00 g,4.69mmol, 1.00 equiv) in dichloromethane(20 mL) was treated with Dess-Martin periodinane(2.10g,4.95 mmol, 1.06 equiv) in two batches a few min apart at 0 °C. After 10 min, the ice bath wasremoved, and the reaction was monitored by TLC (50% ethyl acetate, PMA stain). After 30 min.the reaction was diluted with ethyl acetate and washed twice with satd sodium bicarbonate. Theorganic layer was dried over sodium sulfate, filtered, and concentrated. The crude product waspurified by flash chromatography (80g silica gel, 10 to 50% ethyl acetate/heptane; pure fractionswere identified by TLC with PMA stain; an unidentified impurity elutes slightly earlier than theproduct) to give tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate as a white solid (721 mg,73%). mp 114.5-116C.

References

[1] Patent: CN106565706, 2017, A. Location in patent: Paragraph 0176; 0177; 0178
[2] Organic Letters, 2009, vol. 11, # 16, p. 3523 - 3525
[3] Patent: US2011/319381, 2011, A1. Location in patent: Page/Page column 15
[4] Patent: US2012/129830, 2012, A1. Location in patent: Page/Page column 13
[5] Patent: WO2015/48507, 2015, A1. Location in patent: Paragraph 0219

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Suppliers

China 178 Germany 1 India 4 United Kingdom 1 United States 14 Global 198

Aikon International Limited

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View Lastest Price from tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-05

Zibo Hangyu Biotechnology Development Co., Ltd

Product: tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5
Price: US $100.00-1600.00/g
Min. Order: 5g
Purity: 99%
Supply Ability: 30
Release date: 2024-07-11

Shaanxi Dideu Medichem Co. Ltd

Product: tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-27

1181816-12-5, tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylateRelated Search:

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6-Oxo-2-azaspiro[3.3]heptane-2-carboxylic acid dimethylethyl ester

tert-Butyl 7-oxo-2-azaspiro[3.4]octane-2-carboxylate

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-ca

6-oxo-2-azaspiro[3.3]heptane-2-carboxyL

ert-Butyl6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate

1181816-12-5

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MFCD22421762 oldold