3-Methyl-4-(4-morpholinyl)aniline

Product Name: 3-Methyl-4-(4-morpholinyl)aniline
CAS No.: 112900-82-0
Chemical Name: 3-Methyl-4-(4-morpholinyl)aniline
Synonyms: 3-Methyl-4-morpholinoaniline;3-methyl-4-morpholin-4-ylaniline;3-Methyl-4-(4-morpholinyl)aniline;3-methyl-4-(4-morpholinyl)Benzenamine;Benzenamine, 3-methyl-4-(4-morpholinyl)-
CBNumber: CB02481744
Molecular Formula: C11H16N2O
Formula Weight: 192.26
MOL File: 112900-82-0.mol

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3-Methyl-4-(4-morpholinyl)aniline Property

Boiling point:: 373.8±42.0 °C(Predicted)
Density: 1.122±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: 7.25±0.40(Predicted)
Appearance: Light yellow to brown Solid

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Safety

HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M725413
Product name: 3-Methyl-4-morpholinoaniline
Packaging: 250mg
Price: $240
Updated: 2021/12/16

Apolloscientific

Product number: OR910928
Product name: 3-Methyl-4-morpholinoaniline
Purity: 96%
Packaging: 1g
Price: $285
Updated: 2021/12/16

Matrix Scientific

Product number: 051300
Product name: 3-Methyl-4-(4-morpholinyl)aniline
Packaging: 2.500g
Price: $377
Updated: 2021/12/16

Matrix Scientific

Product number: 051300
Product name: 3-Methyl-4-(4-morpholinyl)aniline
Packaging: 500mg
Price: $123
Updated: 2021/12/16

Apolloscientific

Product number: OR910928
Product name: 3-Methyl-4-morpholinoaniline
Purity: 96%
Packaging: 250mg
Price: $150
Updated: 2021/12/16

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3-Methyl-4-(4-morpholinyl)aniline Chemical Properties,Usage,Production

Synthesis

223404-63-5

112900-82-0

General procedure for the synthesis of 3-methyl-4-morpholinoaniline from 4-(2-methyl-4-nitrophenyl)morpholine: a mixture of 4-(2-methyl-4-nitrophenyl)morpholine (6 g, 0.0645 mol, 1.0 eq.) and zinc powder (8.64 g, 0.135 mol, 5 eq.) in methanol (50 mL) in a round-bottomed flask was placed under stirring conditions . Ammonium chloride (7.29 g, 0.135 mol, 5 eq.) was slowly added at 0 °C, followed by stirring the reaction mixture at room temperature for 1 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was filtered through a bed of diatomaceous earth and the filtrate was concentrated under reduced pressure to obtain the residue. The residue was diluted with dichloromethane (DCM, 150 mL) and washed with water. The organic layer was separated, washed with brine solution, dried over anhydrous sodium sulfate, and finally concentrated under reduced pressure to give 3-methyl-4-morpholinoaniline as a brown solid (5 g, 96.35% yield).1H NMR (400 MHz, CDCl3) data: δ 6.768 (d, 1H), 6.39 (s, 1H), 6.36 (d, 1H), 4.66 ( brs, 2H), 3.681 (t, 4H), 2.683 (t, 4H), 2.124 (s, 3H).

References

[1] Patent: WO2005/105761, 2005, A1. Location in patent: Page/Page column 36
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 5099 - 5119
[3] Patent: WO2015/38417, 2015, A1. Location in patent: Page/Page column 94; 95
[4] Patent: CN108690043, 2018, A. Location in patent: Paragraph 0262; 0266-0267
[5] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 4, p. 353 - 360

3-Methyl-4-(4-morpholinyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Methyl-4-(4-morpholinyl)aniline Suppliers

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View Lastest Price from 3-Methyl-4-(4-morpholinyl)aniline manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Methyl-4-(4-morpholinyl)aniline 112900-82-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

112900-82-0, 3-Methyl-4-(4-morpholinyl)anilineRelated Search:

3-Methyl-4-(4-morpholinyl)aniline

3-Methyl-4-morpholinoaniline

3-methyl-4-morpholin-4-ylaniline

3-methyl-4-(4-morpholinyl)Benzenamine

Benzenamine, 3-methyl-4-(4-morpholinyl)-

112900-82-0