4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester

Product Name: 4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
CAS No.: 24136-23-0
Chemical Name: 4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
Synonyms: MBX 102;JNJ 39659100;Arhalofenate;MBX-102 >=98% (HPLC);Rizatriptan Impurity 24;Arhalofenate, 10 mM in DMSO;4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester;(aR)-4-Chloro-a-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester;Benzeneaceticacid,4-chloro-α-[3-(trifluoromethyl)phenoxy]-,2-(acetylamino)ethylester,(αR)-;Benzeneacetic acid, 4-chloro-α-[3-(trifluoromethyl)phenoxy]-, 2-(acetylamino)ethyl ester, (αR)-
CBNumber: CB02484831
Molecular Formula: C19H17ClF3NO4
Formula Weight: 415.79
MOL File: 24136-23-0.mol

More

Less

4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester Property

Boiling point:: 551.1±50.0 °C(Predicted)
Density: 1.331
storage temp.: 2-8°C
solubility: DMSO: ≥35mg/mL
pka: 15.32±0.46(Predicted)
form: powder
color: white to tan

More

Less

Safety

Hazard Codes: T,N
Risk Statements: 25-36-50/53
Safety Statements: 26-45-60-61
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0064
Product name: MBX-102
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $145
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0064
Product name: MBX-102
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $592
Updated: 2022/05/15

TRC

Product number: M198515
Product name: MBX102
Packaging: 5mg
Price: $495
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC101484
Product name: 4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
Packaging: 10mg
Price: $550
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC101484
Product name: 4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
Packaging: 2mg
Price: $180
Updated: 2021/12/16

More

Less

4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester Chemical Properties,Usage,Production

Uses

MBX 102 is used as a new medication to treat and prevent acute gouty flares, also used as URAT 1 inhibitor.

Biological Activity

MBX-102 has a potent transrepression effect on PPARγ. It is an oral glucose-reducing agent and also has insulin-sensitizing properties. It is useful as treatment for type 2 diabetes. MBX-102 also lowers triglycerides in a PPARα-independent manner.', 'MBX-102 is a selective PPAR modulator (SPPARM) and has been shown to inhibit phosphorylation of PPARγ. MBX-102 is converted to the active form, MBX-102 acid, in vivo.

in vivo

Arhalofenate (MBX 102) (100 mg/kg, p.o.) significantly increases the glucose infusion rate and decreases hepatic glucose output in the clamped state in Zucker Diabetic Fatty (ZDF) rats. Arhalofenate (MBX 102) (60 mg/kg) leads to a dramatic decrease in plasma and also results in a dose-dependent, significant decrease in the insulin resistance indexinsulin levels^[1]. Arhalofenate (MBX 102) (100 mg/kg, p.o.) significantly decreases triglyceride, free fatty acid, and cholesterol levels in ZDF rats. MBX-102 significantly reduces fasting blood glucose, confirming that Arhalofenate (MBX 102) is an efficacious antidiabetic agent. Arhalofenate (MBX 102) (100 mg/kg, p.o.) also significantly lowers fasting plasma insulin, and robustly decreases fasting plasma triglycerides after 32 days of treatment in Zucker Fatty (ZF) rats^[2].

IC 50

PPAR-γ

4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester Suppliers

China 21 United Kingdom 1 United States 7 USA 1 Global 30

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4181
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

guoyungurui

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 10335
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Lingmei Experimental Instruments (Shanghai) Co., Ltd.

Tel: 15356162092
Country: CHINA
ProdList: 141
Advantage: 58

Aoki Biotechnology (Shenzhen) Co., Ltd.

Tel: 18566777408
Country: CHINA
ProdList: 156
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

china yangtze pchem co ltd

Tel: --
Fax: --
Email: pchemchina@hotmail.com
Country: China
ProdList: 58
Advantage: 30

24136-23-0, 4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl esterRelated Search:

MBX 102

Arhalofenate

JNJ 39659100

(aR)-4-Chloro-a-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester

Benzeneacetic acid, 4-chloro-α-[3-(trifluoromethyl)phenoxy]-, 2-(acetylamino)ethyl ester, (αR)-

4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester

Benzeneaceticacid,4-chloro-α-[3-(trifluoromethyl)phenoxy]-,2-(acetylamino)ethylester,(αR)-

MBX-102 >=98% (HPLC)

JNJ-39659100,MBX102,Arhalofenate,Inhibitor,MBX-102,inhibit,PPAR,Peroxisome proliferator-activated receptors,JNJ39659100

Rizatriptan Impurity 24

Arhalofenate, 10 mM in DMSO

24136-23-0