4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
- Product Name
- 4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
- CAS No.
- 24136-23-0
- Chemical Name
- 4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
- Synonyms
- MBX 102;JNJ 39659100;Arhalofenate;MBX-102 >=98% (HPLC);Rizatriptan Impurity 24;Arhalofenate, 10 mM in DMSO;4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester;(aR)-4-Chloro-a-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester;Benzeneaceticacid,4-chloro-α-[3-(trifluoromethyl)phenoxy]-,2-(acetylamino)ethylester,(αR)-;Benzeneacetic acid, 4-chloro-α-[3-(trifluoromethyl)phenoxy]-, 2-(acetylamino)ethyl ester, (αR)-
- CBNumber
- CB02484831
- Molecular Formula
- C19H17ClF3NO4
- Formula Weight
- 415.79
- MOL File
- 24136-23-0.mol
4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester Property
- Boiling point:
- 551.1±50.0 °C(Predicted)
- Density
- 1.331
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥35mg/mL
- pka
- 15.32±0.46(Predicted)
- form
- powder
- color
- white to tan
Safety
- Hazard Codes
- T,N
- Risk Statements
- 25-36-50/53
- Safety Statements
- 26-45-60-61
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0064
- Product name
- MBX-102
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $145
- Updated
- 2025/07/31
- Product number
- SML0064
- Product name
- MBX-102
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $592
- Updated
- 2022/05/15
- Product number
- M198515
- Product name
- MBX102
- Packaging
- 5mg
- Price
- $495
- Updated
- 2021/12/16
- Product number
- FC101484
- Product name
- 4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- FC101484
- Product name
- 4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
- Packaging
- 2mg
- Price
- $180
- Updated
- 2021/12/16
4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester Chemical Properties,Usage,Production
Uses
MBX 102 is used as a new medication to treat and prevent acute gouty flares, also used as URAT 1 inhibitor.
Biological Activity
MBX-102 has a potent transrepression effect on PPARγ. It is an oral glucose-reducing agent and also has insulin-sensitizing properties. It is useful as treatment for type 2 diabetes. MBX-102 also lowers triglycerides in a PPARα-independent manner.', 'MBX-102 is a selective PPAR modulator (SPPARM) and has been shown to inhibit phosphorylation of PPARγ. MBX-102 is converted to the active form, MBX-102 acid, in vivo.
in vivo
Arhalofenate (MBX 102) (100 mg/kg, p.o.) significantly increases the glucose infusion rate and decreases hepatic glucose output in the clamped state in Zucker Diabetic Fatty (ZDF) rats. Arhalofenate (MBX 102) (60 mg/kg) leads to a dramatic decrease in plasma and also results in a dose-dependent, significant decrease in the insulin resistance indexinsulin levels[1]. Arhalofenate (MBX 102) (100 mg/kg, p.o.) significantly decreases triglyceride, free fatty acid, and cholesterol levels in ZDF rats. MBX-102 significantly reduces fasting blood glucose, confirming that Arhalofenate (MBX 102) is an efficacious antidiabetic agent. Arhalofenate (MBX 102) (100 mg/kg, p.o.) also significantly lowers fasting plasma insulin, and robustly decreases fasting plasma triglycerides after 32 days of treatment in Zucker Fatty (ZF) rats[2].
IC 50
PPAR-γ