2-Amino-6-chloronicotinamide
- Product Name
- 2-Amino-6-chloronicotinamide
- CAS No.
- 64321-24-0
- Chemical Name
- 2-Amino-6-chloronicotinamide
- Synonyms
- 100007;Pafolacianine Impurity 23;2-Amino-6-chloronicotinamide;2-Amino-6-chloropyridin-3-carboxamide;2-AMino-6-chloropyridine-3-carboxaMide;2-Amino-6-chloro-3-pyridinecarboxamide;3-PyridinecarboxaMide, 2-aMino-6-chloro-
- CBNumber
- CB02500575
- Molecular Formula
- C6H6ClN3O
- Formula Weight
- 171.58
- MOL File
- 64321-24-0.mol
2-Amino-6-chloronicotinamide Property
- Boiling point:
- 334.8±42.0 °C(Predicted)
- Density
- 1.484
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 14.31±0.50(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H6ClN3O/c7-4-2-1-3(6(9)11)5(8)10-4/h1-2H,(H2,8,10)(H2,9,11)
- InChIKey
- RZXHKUYBBAQDGZ-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(Cl)=CC=C1C(N)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H319Causes serious eye irritation
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A578525
- Product name
- 2-Amino-6-chloronicotinamide
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 067231
- Product name
- 2-Amino-6-chloro-3-pyridinecarboxamide
- Purity
- 95%
- Packaging
- 500mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- FA29252
- Product name
- 2-Amino-6-chloronicotinamide
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 067231
- Product name
- 2-Amino-6-chloro-3-pyridinecarboxamide
- Purity
- 95%
- Packaging
- 1g
- Price
- $162
- Updated
- 2021/12/16
- Product number
- FA29252
- Product name
- 2-Amino-6-chloronicotinamide
- Packaging
- 500mg
- Price
- $180
- Updated
- 2021/12/16
2-Amino-6-chloronicotinamide Chemical Properties,Usage,Production
Synthesis
58584-92-2
64321-24-0
General procedure for the synthesis of 2-amino-6-chloronicotinamide (Inter.3) from 2-amino-6-chloronicotinic acid (Inter.2): Thionyl chloride (3.3 eq.) was added drop-wise to an anhydrous THF solution of 0.3 M 2-amino-6-chloronicotinic acid (1 eq.) under inert atmosphere. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was concentrated in vacuum to give a crude yellow solid residue. The crude solid was dissolved in THF in the same volume as the initial reaction volume and concentrated again under vacuum to give a yellow solid residue. After repeating this dissolution and concentration process once, the residue was dissolved in THF (prepared as a 0.3 M solution) and ammonia was passed into the solution for 1 hour. The resulting precipitate was removed by filtration and the filtrate was concentrated under vacuum to give a yellow precipitate. The precipitate was ground in water at 50 °C and subsequently dried to afford the target compound 2-amino-6-chloronicotinamide (92% yield, 93% purity). The product was analyzed by LC-MS, m/z (ESP): 172 [M + H]+, retention time (R/T) = 3.19 min. The purity of the product met the requirements for use and no further purification was required.
References
[1] Patent: US2009/99174, 2009, A1
[2] Patent: WO2007/60404, 2007, A1. Location in patent: Page/Page column 57-58
[3] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 100
[4] Patent: WO2014/205593, 2014, A1. Location in patent: Page/Page column 59
[5] Patent: US2003/187026, 2003, A1
2-Amino-6-chloronicotinamide Preparation Products And Raw materials
Raw materials
Preparation Products
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