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TW-37

Product Name
TW-37
CAS No.
877877-35-5
Chemical Name
TW-37
Synonyms
TW-37;CS-299;TW37;TW 37;TW-37 ，S1121;TW-37 USP/EP/BP;TW-37/Bcl-2Inhibitor;TW-37, 10 mM in DMSO;inhibit,Bcl-2 Family,TW37,TW-37,Inhibitor;5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide;N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide
CBNumber
CB02500999
Molecular Formula
C33H35NO6S
Formula Weight
573.7
MOL File
877877-35-5.mol
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TW-37 Property

Boiling point:
723.7±60.0 °C(Predicted)
Density 
1.280
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥19.75 mg/mL in DMSO; ≥3.41 mg/mL in EtOH with gentle warming and ultrasonic
form 
A crystalline solid
pka
7.86±0.50(Predicted)
color 
White to off-white
InChIKey
PQAPVTKIEGUPRN-UHFFFAOYSA-N
SMILES
C(NC1=CC=C(S(C2=CC=CC=C2C(C)(C)C)(=O)=O)C=C1)(=O)C1=CC(CC2=CC=CC=C2C(C)C)=C(O)C(O)=C1O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20999
Product name
TW-37
Purity
≥98%
Packaging
5mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
20999
Product name
TW-37
Purity
≥98%
Packaging
10mg
Price
$185
Updated
2024/03/01
Cayman Chemical
Product number
20999
Product name
TW-37
Purity
≥98%
Packaging
25mg
Price
$380
Updated
2024/03/01
Cayman Chemical
Product number
20999
Product name
TW-37
Purity
≥98%
Packaging
50mg
Price
$648
Updated
2024/03/01
Tocris
Product number
4038
Product name
TW37
Purity
≥97%(HPLC)
Packaging
50
Price
$835
Updated
2021/12/16
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TW-37 Chemical Properties,Usage,Production

Description

TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively). It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells. TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously. It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.

Uses

TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.

Uses

TW-37 is a Bcl-2 inhibitor that suppresses growth and enhance cisplatin-induced apoptosis in ovarian cancer cells. Also functions as an MCL-1 inhibitor that kills many more malignant cells.

Definition

ChEBI: N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide is a member of benzamides.

in vivo

A murine model of humanized vasculature is used to investigate the biological effect of TW-37 (TW37) on human microvascular endothelial cell in vivo. Using this model, a significant decrease is observed in total blood vessel number (P<0.05) comparing both 3 and 30 mg/kg TW-37 against vehicle control. In addition to reduction in total number of blood vessels, an unusual number of occluded vessels are occurring in the treated groups. The levels of vessel occlusion are assessed by counting completely blocked vessels and determining their number as a percentage of total vessel number. TW-37 concentration mediates a significant increase in the number of occluded vessels when compared with control[1].

IC 50

Mcl-1: 260 nM (Ki); Bcl-2: 290 nM (Ki); Bcl-xL: 1110 nM (Ki)

References

[1] MONIQUE VERHAEGEN. A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.[J]. Cancer research, 2006, 66 23: 11348-11359. DOI: 10.1158/0008-5472.can-06-1748
[2] BENJAMIN D ZEITLIN. Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2.[J]. Cancer research, 2006, 66 17: 8698-8706. DOI: 10.1158/0008-5472.can-05-3691
[3] ASFAR S. AZMI  Ramzi M M. Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy[J]. Journal of Cellular Physiology, 2008, 218 1: 13-21. DOI: 10.1002/jcp.21567

TW-37 Preparation Products And Raw materials

Raw materials

Preparation Products

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TW-37 Suppliers

China 101 India 1 United Kingdom 2 United States 22 Global 126
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
ApexBio Technology LLC
Tel
+1-832-696-8203
Fax
+1-832-641-3177
Email
info@apexbt.com
Country
United States
ProdList
477
Advantage
60
Accela ChemBio Inc.
Tel
+1(858) 699-3322
Fax
+1(858) 876-1948
Email
marketing@accelachem.com
Country
United States
ProdList
6024
Advantage
65
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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58
United States Biological
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sales@advtechind.com
Country
United States
ProdList
6075
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58
ApexBio Technology
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United States
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Selleck Chemicals LLC
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info@selleckchem.com
Country
United States
ProdList
824
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60
Abcam Limited
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us.orders@abcam.com
Country
United States
ProdList
6001
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50
Cayman Chemical Company
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Email
cayman@caymanchem.com
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United States
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United States Biological
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chemicals@usbio.net
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Creative Enzymes
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MedChemExpress
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Matrix Scientific
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sales@matrixscientific.com
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United States
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6632
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Exlcusive Chemistry Ltd
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Santa Cruz Biotechnology, Inc.
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3597
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View Lastest Price from TW-37 manufacturers

Career Henan Chemical Co
Product
TW-37 877877-35-5
Price
US $0.01/KG
Min. Order
500g
Purity
98%; 99%
Supply Ability
500g；1kg； 10kg; 25kg
Release date
2020-01-08

877877-35-5, TW-37Related Search:

ABT-199 Panobinostat ABT 737 ABT 263 Obatoclax mesilate CHIR-99021

  • TW-37
  • N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide
  • N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide
  • N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide
  • 5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide
  • N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide TW-37
  • Bcl-2 Inhibitor N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide
  • CS-299
  • TW37;TW 37
  • Benzamide, N-[4-[[2-(1,1-dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]-
  • N-{4-[(2-tert-butylbenzene)sulfonyl]phenyl}-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide
  • TW-37 USP/EP/BP
  • N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide
  • inhibit,Bcl-2 Family,TW37,TW-37,Inhibitor
  • TW-37/Bcl-2Inhibitor
  • TW-37/N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide
  • TW-37, 10 mM in DMSO
  • TW-37 ，S1121
  • 877877-35-5
  • 33H35NO6S
  • C33H35NO6S
  • Inhibitor
  • Inhibitors