ChemicalBook > CAS DataBase List > 4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine

4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine

Product Name
4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine
CAS No.
477845-12-8
Chemical Name
4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine
Synonyms
PIM-1 Inhibitor 2;PIM1 Kinase Inhibitor IV;PIM1 Inhibitor 2,PIM 1 Inhibitor 2;4-(3-(4-chlorophenyl)benzo[c]isoxazol-5-yl)pyrimidin-2-amine;4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine;2-Pyrimidinamine, 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]-
CBNumber
CB02518918
Molecular Formula
C17H11ClN4O
Formula Weight
322.75
MOL File
477845-12-8.mol
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4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine Property

Boiling point:
627.1±65.0 °C(Predicted)
Density 
1.398±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
Soluble to 75 mM in DMSO
form 
Yellow solid
pka
2.98±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17809
Product name
Pim-1 Inhibitor 2
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17809
Product name
Pim-1 Inhibitor 2
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
17809
Product name
Pim-1 Inhibitor 2
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
Tocris
Product number
3589
Product name
PIM-1Inhibitor2
Purity
≥98%(HPLC)
Packaging
50
Price
$488
Updated
2021/12/16
Tocris
Product number
3589
Product name
PIM-1Inhibitor2
Purity
≥98%(HPLC)
Packaging
10
Price
$120
Updated
2021/12/16
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4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine Chemical Properties,Usage,Production

Uses

Pim-1 is a serine/threonine kinase that targets proteins involved in cell survival and proliferation and has roles in tumorigenesis. Pim-1 inhibitor 2 is a potent Pim-1 inhibitor (Ki = 91 nM) that targets the ATP-binding kinase hinge region.[Cayman Chemical]

Uses

Pim-1 Inhibitor 2 acts as a serione/threonine kinase targeting proteins involved in cell proliferation and survical. Potential anti-tumor agent.

IC 50

PIM1: 91 nM (Ki)

4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine Suppliers

China 29 United Kingdom 1 United States 5 USA 1 Global 36
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

477845-12-8, 4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamineRelated Search:


  • PIM1 Kinase Inhibitor IV
  • 4-(3-(4-chlorophenyl)benzo[c]isoxazol-5-yl)pyrimidin-2-amine
  • 4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine
  • PIM-1 Inhibitor 2
  • PIM1 Inhibitor 2,PIM 1 Inhibitor 2
  • 2-Pyrimidinamine, 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]-
  • 477845-12-8
  • C17H11CIN4O