PH 797804

Product Name: PH 797804
CAS No.: 586379-66-0
Chemical Name: PH 797804
Synonyms: 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide;CS-45;PH 797804;PH-797804, >=98%;PH 797804;PH797804;PH 797804 USP/EP/BP;PH-797804 PH797804 MAPK Inhibitor;PH 797804, (±)- - rac-PH 797804 | rac-PH 797804;3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide;3-Bromo-4-[(2,4-difluorobenzyl)oxy]-1-[5-[(methylamino)carbonyl]-2-methylphenyl]-6-methylpyridin-2(1H)-one
CBNumber: CB02522106
Molecular Formula: C22H19BrF2N2O3
Formula Weight: 477.3
MOL File: 586379-66-0.mol

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PH 797804 Property

Density: 1.51
storage temp.: 20-25°C
solubility: ≥23.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: powder
color: white to beige
CAS DataBase Reference: 586379-66-0

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0259
Product name: PH-797804
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $112
Updated: 2023/06/20

Sigma-Aldrich

Product number: PZ0259
Product name: PH-797804
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $451
Updated: 2023/06/20

Cayman Chemical

Product number: 20244
Product name: PH-797804
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 20244
Product name: PH-797804
Purity: ≥98%
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 20244
Product name: PH-797804
Purity: ≥98%
Packaging: 10mg
Price: $321
Updated: 2024/03/01

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PH 797804 Chemical Properties,Usage,Production

Uses

PH-797804 is a novel N-phenylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase derived from a racemic mixture as the more potent atropisomer and is also known to exerts anti-inflammatory properties.

Definition

ChEBI: A member of the class of benzamides obtained by formal condensation of the carboxy group of 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1-yl}-4-methylbenzoic acid with the amino group of methylamine.

Biological Activity

ph-797804 is a novel, potent, atp-competitive and reversible inhibitor of human p38 map kinase. it specifically inhibits p38α with ic50 value of 26 nm and k(i) value of 5.8 nm.ph-797804 inhibits lps induced tnf-α and il-1β production in monocytes with a concentration-dependently manner. ph-797804 blocks rankl and m-csf induced osteoclast formation in primary rat bone marrow cells.orally administered ph-797804 suppresses tnf-α level in a dose-dependent manner in lps induced lewis rats and also in cynomolgus monkeys. additionally, ph-797804 has been shown to inhibit chronic inflammation in arthritis models induced by mouse collagen-induced or rat streptococcal cell wall (scw) extract.

Biochem/physiol Actions

PH-797804 is an orally active, potent and readily reversible ATP competitive inhibitor of the alpha isoform of human p38 MAP kinase. PH-797804 blocks inflammation-induced production of cytokines and proinflammatory mediators.

target

p38α

References

[1] hope hr1, anderson gd, burnette bl, compton rp, devraj rv, hirsch jl, keith rh, li x, mbalaviele g, messing dm, saabye mj,schindler jf, selness sr, stillwell li, webb eg, zhang j, monahan jb. anti-inflammatory properties of a novel n-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. j pharmacol exp ther. 2009 dec;331(3):882-95.

PH 797804 Preparation Products And Raw materials

Raw materials

Preparation Products

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PH 797804 Suppliers

Canada 1 China 81 India 1 United Kingdom 1 United States 15 Global 99

AdooQ BioScience, LLC

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Target molecule Corp.

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InvivoChem

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Cckinase, Inc.

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Aladdin Scientific

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Creative Enzymes

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586379-66-0, PH 797804Related Search:

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3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide

PH 797804

3-Bromo-4-[(2,4-difluorobenzyl)oxy]-1-[5-[(methylamino)carbonyl]-2-methylphenyl]-6-methylpyridin-2(1H)-one

3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide

PH-797804, >=98%

PH 797804, (±)- - rac-PH 797804 | rac-PH 797804

PH 797804;PH797804

CS-45

PH 797804 USP/EP/BP

3-ChemicalbookBromo-4-[(2,4-difluorobenzyl)oxy]-1-[5-[(methylamino)carbonyl]-2-methylphenyl]-6-methylpyridin-2(1H)-one

PH-797804 PH797804 MAPK Inhibitor

586379-66-0

C22H19BrF2N2O3

MAPK

Inhibitors