ChemicalBook > CAS DataBase List > N-Ethyl-p-menthane-3-carboxamide

N-Ethyl-p-menthane-3-carboxamide

Product Name
N-Ethyl-p-menthane-3-carboxamide
CAS No.
39711-79-0
Chemical Name
N-Ethyl-p-menthane-3-carboxamide
Synonyms
WS-3;Menthol Carboxamide;ETHYL MENTHANE CARBOXAMIDE;Cooling Agent WS-3;N,2,3-trimethyl-2isopropl butanamide;FEMA 3455;Cooling taste agent ws-23;N-Ethyl-PARA-Menthan-3-Carboxamide;N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE;N-Ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
CBNumber
CB0252522
Molecular Formula
C13H25NO
Formula Weight
211.34
MOL File
39711-79-0.mol
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N-Ethyl-p-menthane-3-carboxamide Property

Melting point:
87-102 °C
Boiling point:
351.04°C (rough estimate)
alpha 
D -49 to -54°
Density 
0.9305 (rough estimate)
vapor pressure 
0.007Pa at 25℃
refractive index 
1.4410 (estimate)
FEMA 
3455 | N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: ≥ 100 mg/mL (473.17 mM); Water: < 0.1 mg/mL (insoluble)
pka
16.27±0.60(Predicted)
form 
powder to crystal
color 
White to Almost white
Odor
at 25.00 % in dipropylene glycol. mild mentholic minty
Odor Type
minty
Water Solubility 
insoluble
JECFA Number
1601
Merck 
14,3825
InChIKey
VUNOFAIHSALQQH-UHFFFAOYSA-N
LogP
2.902 at 25℃
CAS DataBase Reference
39711-79-0(CAS DataBase Reference)
EPA Substance Registry System
Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)- (39711-79-0)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36-41-22
Safety Statements 
39-26
WGK Germany 
2
HS Code 
29242990
Toxicity
LD50 in mice, rats (g/kg): 5.3, 2.9 orally (Parrish)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W345501
Product name
N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity
99%
Packaging
sample-k
Price
$54.6
Updated
2024/03/01
Sigma-Aldrich
Product number
W345501
Product name
N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity
99%, FG
Packaging
100g
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
W345501
Product name
N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity
99%, FG
Packaging
1kg
Price
$690
Updated
2024/03/01
Sigma-Aldrich
Product number
W345501
Product name
N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity
99%, FG
Packaging
5kg
Price
$1460
Updated
2024/03/01
TCI Chemical
Product number
E0796
Product name
N-Ethyl-p-menthane-3-carboxamide
Purity
>98.0%(GC)
Packaging
5g
Price
$19
Updated
2024/03/01
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N-Ethyl-p-menthane-3-carboxamide Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Chemical Properties

N-ethyl-p-menthane-3-carboxamide is an odorless white, crystalline solid. The compound has a strong and clear physiological cooling effect and is used mainly in oral care products.

Chemical Properties

Slight menthol-like cooling effect aroma

Uses

WS 3 is a selective transient receptor potential melastatin-8 ligand.

Uses

Physiological coolant in foods, beverages, toiletries, cosmetics and pharmaceuticals.

Definition

ChEBI: Ethyl menthane carboxamide is a p-menthane monoterpenoid.

Aroma threshold values

Aroma characteristics at 1.0%. Virtually odorless

Taste threshold values

Taste characteristics at 10 to 100 ppm. Intense lingering cooling. The cooling sensation builds slow but steadily and grows to a lingering cooling mouthfeel with a slightly camphoraceous and minty character.

Flammability and Explosibility

Not classified

Trade name

Winsense WS-3 (Renessenz)

Biological Activity

Cooling agent that is an agonist at TRPM8 receptors (EC 50 = 3.7 μ M).

Synthesis

0.89 g (0.0091 mol) of polyphosphoric acid (85%) and 0.42 g (0.0091 mol) of ethanol were weighed. 0.54 g (0.0046 mol) of diethylcarbonate was added dropwise slowly while cooling in an ice bath, wherein the temperature increases slightly. After about 5 minutes, 0.5 g (0.0030 mol) of p-menthane-3-carbonitrile was added. The reaction solution was heated and stirred for 102 hours at 150??C. At the end of the reaction by GC, about 70% of desired N-Ethyl-p-menthane-3-carboxamide was formed.Fig The synthetic method 1 of N-Ethyl-p-menthane-3-carboxamide

N-Ethyl-p-menthane-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Ethyl-p-menthane-3-carboxamide Suppliers

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View Lastest Price from N-Ethyl-p-menthane-3-carboxamide manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Cooling Agent Ws-3 39711-79-0
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-30
Hebei Weibang Biotechnology Co., Ltd
Product
N-Ethyl-p-menthane-3-carboxamide 39711-79-0
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 mt
Release date
2024-11-19
Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
N-Ethyl-p-menthane-3-carboxamide 39711-79-0
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
99%
Supply Ability
20tons
Release date
2023-12-23

39711-79-0, N-Ethyl-p-menthane-3-carboxamideRelated Search:

Methyl acetate Formamide Methylparaben Ethyl cellulose Acrylamide Basic Violet 1 Polyacrylamide Isopropyl alcohol Isopropyl acetate N,N-Dimethylformamide Acetamide Methyl acrylate Polyamide Methanol Ethyl acetate Acetonitrile Kresoxim-methyl Ethyl acrylate

  • Cooling taste agent ws-23
  • N,2,3-trimethyl-2isopropl butanamide
  • N-Ethyl-2-(isopropyl)-5-methylcyclohexanecarboxamide N-Ethyl-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide Ethyl menthane carboxamide Framidice 3 Menthol Carboxamide WS-3
  • FEMA 3455
  • WS-3
  • Menthol Carboxamide
  • N-Ethyl-PARA-Menthan-3-Carboxamide
  • TRPM8 antagonist WS-3
  • Cooling Agent WS-3
  • N-ETHYL-5-METHYL-2-(1-METHYLETHYL)-CYCLOHEXANE-CARBOXAMIDE
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  • N-ETHYL-P-MENTHAN 3-CARBOXAMIDE
  • N-ETHYL-P-MENTHANE-3-CARBOXAMIDE
  • ETHYL MENTHANE CARBOXAMIDE
  • n-ethyl-5-methyl-2-(1-methylethyl)-cyclohexanecarboxamid
  • MENTHANE CARBOXAMIDE
  • N-Ethyl-hexahydro-p-cymene-3-carboxamide
  • Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)-
  • N-ETHYL-PARA-MENTHANE-3-CARBOXAMIDE
  • N-Ethyl-2-(isopropyl)-5-methylcyclohexancarboxamid
  • N-Ethyl-p-methane-3-carboxamide, Ethyl menthane carboxamide, Framidice 3, Menthol Carboxamide WS-3
  • Menthol Carboxamide WS-3
  • N-Ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
  • N-Ethyl-2-isopropyl-5-methylcyclohexane-1-carboxamide
  • N-Ethyl-p-menthane-3-carboxamide,99%
  • Ethyl menthane carboxamide Framidice 3
  • N-Ethyl-p-menthane-3
  • TIMTEC-BB SBB008527
  • CoolingSensate WS 3
  • N-ETHYL-PARA-MENTHAN-3-CARBOXAMIDE cooling agent
  • (1R,2R,5S)-N-ethyl-5-methyl-2-propan-2-yl-1-cyclohexanecarboxamide
  • N-Ethyl-p-menthane-3-carboxamide&gt
  • N-Ethyl-p-menthane-3-carboxamide（Cooling taste agent WS-23）
  • -p-menthane-3-carboxamide
  • N-Ethyl-p-menthane-3-carboxamide ISO 9001：2015 REACH
  • Cool taste WS - 3
  • N-ETHYL-P-MENTHAN-3-CARBOXAMIDE(WS-3)
  • N-Ethyl-2-isopropyl-5-methylcyclohexane ? ?carboxamide(WS-3)
  • (1R,2S,5R)-N-Ethyl-p-menthane-3-carboxamide
  • 39711-79-0