NBI 35965 hydrochloride

Product Name: NBI 35965 hydrochloride
CAS No.: 603151-83-3
Chemical Name: NBI 35965 hydrochloride
Synonyms: NBI-35965 Mesylate;NBI 35965 hydrochloride;NBI 35965 methanesulfonate
CBNumber: CB02535685
Molecular Formula: C22H26Cl2N4O3S
Formula Weight: 497.43784
MOL File: 603151-83-3.mol

More

Less

NBI 35965 hydrochloride Property

Melting point:: 167 °C
storage temp.: Store at -20°C
solubility: Soluble in DMSO > 10 mM
form: Powder

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 18524
Product name: NBI 35965 (mesylate)
Purity: ≥95%
Packaging: 1 mg
Price: $30
Updated: 2024/03/01

Cayman Chemical

Product number: 18524
Product name: NBI 35965 (mesylate)
Purity: ≥95%
Packaging: 5mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 18524
Product name: NBI 35965 (mesylate)
Purity: ≥95%
Packaging: 10mg
Price: $148
Updated: 2024/03/01

Cayman Chemical

Product number: 18524
Product name: NBI 35965 (mesylate)
Purity: ≥95%
Packaging: 25mg
Price: $333
Updated: 2024/03/01

Cayman Chemical

Product number: 18524
Product name: NBI 35965 (mesylate)
Purity: ≥95%
Packaging: 50mg
Price: $723
Updated: 2023/01/06

More

Less

NBI 35965 hydrochloride Chemical Properties,Usage,Production

Uses

Corticotropin-releasing hormone, also known as corticotropin-releasing factor (CRF) or corticoliberin, is a peptide hormone and neurotransmitter involved in the stress response. It is secreted from the hypothalamus and is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. NBI 35965 is a selective CRF receptor 1 (CRF1) antagonist with a Ki value of 4 nM. It does not inhibit CRF2 (Ki = >10,000 nM). NBI 35965 inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo. In animal models of stress, NBI 35965 administration produces anxiolytic effects.[Cayman Chemical]

Uses

NBI 35965 Mesylate is a selective corticotropin-releasing factor (CRF1) receptor antagonist involved in stress response.

Uses

NBI 35965 Hydrochloride is a potent and selective corticotropin-releasing factor 1 (CRF1) antagonist.

in vivo

NBI 35965 methanesulfonate (20 mg/kg; oral gavage; once) reduces stress induced ACTH production in mice^[1].
In rats, NBI 35965 methanesulfonate (Compound 12a; 10 mg/kg) has a volume of distribution 17.8 L/kg, a plasma clearance of 17 mL/min/kg, and a half-life of 12 h. The estimated oral bioavailability is 34% with a mean maximal plasma concentration at 1 h of 560 ng/mL. NBI 35965 methanesulfonate also penetrated the blood-brain barrier, resulting in a mean maximal brain concentration of 700 ng/g^[1].

Animal Model:	Male CD-1 mice (24-26 g) bearing restraint stress^[1]
Dosage:	20 mg/kg (10 mL/kg 5% mannitol-d (w/v) in water)
Administration:	Oral gavage; 60 min prior to the initiation of the stressor
Result:	Reduced stress induced ACTH production in vivo.

IC 50

CRFR1: 4 nM (Ki); CRFR1: 8.5 (pKi)

NBI 35965 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

NBI 35965 hydrochloride Suppliers

China 20 United Kingdom 1 United States 6 USA 1 Global 28

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4989
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Tel: 024-024-024-88590548 18341751992
Email: 757984502@qq.com
Country: China
ProdList: 942
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Country: China
ProdList: 892
Advantage: 58

Guangzhou Biopark Technology Co., Ltd.

Tel: 020-83808789
Country: CHINA
ProdList: 179
Advantage: 58

Guangzhou Tuoshan Biotechnology Co., Ltd.

Tel: 19928332050
Country: CHINA
ProdList: 161
Advantage: 58

Aoki Biotechnology (Shenzhen) Co., Ltd.

Tel: 18566777408
Country: CHINA
ProdList: 156
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Jijin Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jijinhuaxue@sina.com
Country: CHINA
ProdList: 6606
Advantage: 58

Shenzhen Xinbosheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: service@neobioscience.com
Country: CHINA
ProdList: 6151
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

603151-83-3, NBI 35965 hydrochlorideRelated Search:

NBI 35965 hydrochloride

NBI-35965 Mesylate

NBI 35965 methanesulfonate

603151-83-3

C21H22Cl2N4HCl