NBI 35965 hydrochloride
- Product Name
- NBI 35965 hydrochloride
- CAS No.
- 603151-83-3
- Chemical Name
- NBI 35965 hydrochloride
- Synonyms
- NBI-35965 Mesylate;NBI 35965 hydrochloride;NBI 35965 methanesulfonate
- CBNumber
- CB02535685
- Molecular Formula
- C22H26Cl2N4O3S
- Formula Weight
- 497.43784
- MOL File
- 603151-83-3.mol
NBI 35965 hydrochloride Property
- Melting point:
- 167 °C
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 18524
- Product name
- NBI 35965 (mesylate)
- Purity
- ≥95%
- Packaging
- 1 mg
- Price
- $30
- Updated
- 2024/03/01
- Product number
- 18524
- Product name
- NBI 35965 (mesylate)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 18524
- Product name
- NBI 35965 (mesylate)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $148
- Updated
- 2024/03/01
- Product number
- 18524
- Product name
- NBI 35965 (mesylate)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $333
- Updated
- 2024/03/01
- Product number
- 18524
- Product name
- NBI 35965 (mesylate)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $723
- Updated
- 2023/01/06
NBI 35965 hydrochloride Chemical Properties,Usage,Production
Uses
Corticotropin-releasing hormone, also known as corticotropin-releasing factor (CRF) or corticoliberin, is a peptide hormone and neurotransmitter involved in the stress response. It is secreted from the hypothalamus and is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. NBI 35965 is a selective CRF receptor 1 (CRF1) antagonist with a Ki value of 4 nM. It does not inhibit CRF2 (Ki = >10,000 nM). NBI 35965 inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo. In animal models of stress, NBI 35965 administration produces anxiolytic effects.[Cayman Chemical]
Uses
NBI 35965 Mesylate is a selective corticotropin-releasing factor (CRF1) receptor antagonist involved in stress response.
Uses
NBI 35965 Hydrochloride is a potent and selective corticotropin-releasing factor 1 (CRF1) antagonist.
in vivo
NBI 35965 methanesulfonate (20 mg/kg; oral gavage; once) reduces stress induced ACTH production in mice[1].
In rats, NBI 35965 methanesulfonate (Compound 12a; 10 mg/kg) has a volume of distribution 17.8 L/kg, a plasma clearance of 17 mL/min/kg, and a half-life of 12 h. The estimated oral bioavailability is 34% with a mean maximal plasma concentration at 1 h of 560 ng/mL. NBI 35965 methanesulfonate also penetrated the blood-brain barrier, resulting in a mean maximal brain concentration of 700 ng/g[1].
| Animal Model: | Male CD-1 mice (24-26 g) bearing restraint stress[1] |
| Dosage: | 20 mg/kg (10 mL/kg 5% mannitol-d (w/v) in water) |
| Administration: | Oral gavage; 60 min prior to the initiation of the stressor |
| Result: | Reduced stress induced ACTH production in vivo. |
IC 50
CRFR1: 4 nM (Ki); CRFR1: 8.5 (pKi)
NBI 35965 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
NBI 35965 hydrochloride Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58