ChemicalBook > CAS DataBase List > (+)-Fluprostenol

(+)-Fluprostenol

Product Name
(+)-Fluprostenol
CAS No.
54276-17-4
Chemical Name
(+)-Fluprostenol
Synonyms
(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid;AL 5848;Travoprost 2;Travoprost Acid;(+)-Fluprostenol;Travoprost Acid-d4;[3H]-Travoprost acid;Travoprost free acid;Ttravoprost free acid;Travoprost impurity E
CBNumber
CB02551360
Molecular Formula
C23H29F3O6
Formula Weight
458.47
MOL File
54276-17-4.mol
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(+)-Fluprostenol Property

Boiling point:
608.0±55.0 °C(Predicted)
Density 
1.335±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated), Dichloromethane, Acetonitrile
form 
Solid
pka
4.76±0.10(Predicted)
color 
Colourless to Pale Yellow Oil
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Safety

HS Code 
2937500000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16768
Product name
Fluprostenol
Purity
≥95%
Packaging
1mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
16768
Product name
Fluprostenol
Purity
≥95%
Packaging
5mg
Price
$280
Updated
2024/03/01
Cayman Chemical
Product number
16768
Product name
Fluprostenol
Purity
≥95%
Packaging
10mg
Price
$497
Updated
2024/03/01
Cayman Chemical
Product number
16768
Product name
Fluprostenol
Purity
≥95%
Packaging
25mg
Price
$1084
Updated
2024/03/01
TRC
Product number
T715620
Product name
TravoprostAcid
Packaging
25mg
Price
$895
Updated
2021/12/16
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(+)-Fluprostenol Chemical Properties,Usage,Production

Uses

A metabolically stable analog of Prostaglandin F2α (P838625) with potent FP receptor agonist activity. An impurity of Travoprost (T715600).

Uses

Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity. Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively. It is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 μg/kg to terminate pregnancy. It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3-10 x 10?11 M.[Cayman Chemical]

Definition

ChEBI: Fluprostenol is an organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea. It has a role as an antiglaucoma drug, an antihypertensive agent, a prostaglandin receptor agonist, a female contraceptive drug and an abortifacient. It is a prostaglandins Falpha, a hydroxy monocarboxylic acid and a member of (trifluoromethyl)benzenes.

(+)-Fluprostenol Preparation Products And Raw materials

Raw materials

Preparation Products

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54276-17-4, (+)-FluprostenolRelated Search:

Tafluprost Iodoethane Ethyl bromoacetate 15(S)-Fluprostenol isopropyl ester Travoprost 15-KETO FLUPROSTENOL 5,6-trans Travoprost 3-Trifluoromethylphenol 15-Keto Travoprost 9-keto Fluprostenol isopropyl ester 9-KETO FLUPROSTENOL (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide 11-KETO FLUPROSTENOL

  • (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid
  • [1R-[1α(Z),2β(1E,3R*),3α,5α]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid
  • 16-(M-TrifluoroMethylphenoxy)-17,18,19,20-tetranorprostaglandin F2α
  • AL 5848
  • Travoprost Acid
  • Ttravoprost free acid
  • Travoprost Acid-d4
  • [3H]-Travoprost acid
  • Travoprost Impurity 12（Fluprostenol）
  • (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid
  • Travoprost Acid/Travoprost USP Related Compound A/(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid
  • Fluprostenol Travoprost acid
  • 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, (5Z)-
  • Travoprost free acid
  • (Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoic acid
  • Travoprost Related Compound A (1673012)Q: What is Travoprost Related Compound A (1673012) Q: What is the CAS Number of Travoprost Related Compound A (1673012)
  • Travoprost impurity E
  • Travoprost 2
  • PTGER2,Oviductal glycoprotein 1,(+) Fluprostenol,inhibit,(+)Fluprostenol,OVGP1,Inhibitor,(+)-Fluprostenol
  • (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E,3R)-3-hydroxy- 4-[3-(trifluoromethyl) phenoxy] but-1-enyl] cyclopentyl]hept-5-enoic acid
  • (+)-Fluprostenol
  • 54276-17-4
  • API
  • Agonists
  • Chiral Reagents
  • Impurities
  • Intermediates & Fine Chemicals
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