CAY10583
- Product Name
- CAY10583
- CAS No.
- 862891-27-8
- Chemical Name
- CAY10583
- Synonyms
- CAY10583;CAY10583 Exclusive;IUJTVDNJFPZYBL-UHFFFAOYSA-N;4'-((N-phenylpentanamido)methyl)-[1,1'-biphenyl]-2-carboxylic acid;4'-[[(1-Oxopentyl)phenylamino]methyl]-[1,1'-biphenyl]-2-carboxylic acid;[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[(1-oxopentyl)phenylamino]methyl]-;4′-[[(1-oxopentyl)phenylamino]methyl]-[1,1′-biphenyl]-2-carboxylic acid, CAS 862891-27-8
- CBNumber
- CB02590431
- Molecular Formula
- C25H25NO3
- Formula Weight
- 387.4709
- MOL File
- 862891-27-8.mol
CAY10583 Property
- Boiling point:
- 562.0±43.0 °C(Predicted)
- Density
- 1.177±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.25 mg/ml
- form
- A crystalline solid
- pka
- 3.84±0.36(Predicted)
- color
- white to beige
- InChI
- InChI=1S/C25H25NO3/c1-2-3-13-24(27)26(21-9-5-4-6-10-21)18-19-14-16-20(17-15-19)22-11-7-8-12-23(22)25(28)29/h4-12,14-17H,2-3,13,18H2,1H3,(H,28,29)
- InChIKey
- IUJTVDNJFPZYBL-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=CC=C1C1=CC=C(CN(C(=O)CCCC)C2=CC=CC=C2)C=C1
N-Bromosuccinimide Price
- Product number
- 10012424
- Product name
- CAY10583
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 10012424
- Product name
- CAY10583
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $112
- Updated
- 2024/03/01
- Product number
- 10012424
- Product name
- CAY10583
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $264
- Updated
- 2024/03/01
- Product number
- 10012424
- Product name
- CAY10583
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $468
- Updated
- 2024/03/01
- Product number
- E588613
- Product name
- 4''-[[(1-oxopentyl)phenylamino]methyl]-[1,1''-biphenyl]-2-carboxylicAcid
- Packaging
- 10mg
- Price
- $90
- Updated
- 2021/12/16
CAY10583 Chemical Properties,Usage,Production
Uses
4''-[[(1-oxopentyl)phenylamino]methyl]-[1,1''-biphenyl]-2-carboxylic acid is a BLT2 agonist.
Definition
ChEBI: [1,1'-biphenyl]-2-carboxylic acid, 4'-[[(1-oxopentyl)phenylamino]methyl]- is a member of biphenyls.
Biological Activity
CAY10583 is a potent and selective full agonist for Leukotriene B4 receptor type 2 (BLT2). CAY10583 promotes wound healing and cell proliferation in cultured intestinal epithelial cells.
in vivo
CAY10583 (administered topically to full-thickness wounds; 10 μM; 14 days) significantly results in a greater wound closure than the control group. The difference in wound closure between the CAY-treated group and the control group is pronounced over time until day 10. And the difference is approximately 6% at day 4 and reaches almost 20% at day 8. Notably, 100% closure was observed in the CAY-treated group at day 14[1].
| Animal Model: | Lewis rats (6-9 weeks of age, 180-220 g)[1] |
| Dosage: | 10 μM; 14 days |
| Administration: | Administered topically to full-thickness wounds; 10 μM; 14 days |
| Result: | Accelerated in vivo wound healing by topical application. |
IC 50
BLT2
CAY10583 Preparation Products And Raw materials
Raw materials
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