ChemicalBook > CAS DataBase List > Varenicline-d4

Varenicline-d4

Product Name
Varenicline-d4
CAS No.
2183239-01-0
Chemical Name
Varenicline-d4
Synonyms
Varenicline-d4;D4-Varenicline;Varenicline Nitroso D4;7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline-7,7,9,9-d4
CBNumber
CB02675994
Molecular Formula
C13H13N3
Formula Weight
211.27
MOL File
2183239-01-0.mol
More
Less

Varenicline-d4 Property

storage temp. 
Store at -20°C
solubility 
Water: 0.0877 mg/mL
form 
A solid
Water Solubility 
Water: 0.0877 mg/mL
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
26102
Product name
Varenicline-d4
Purity
≥99% deuterated forms (d1-d4)
Packaging
500μg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
26102
Product name
Varenicline-d4
Purity
≥99% deuterated forms (d1-d4)
Packaging
1mg
Price
$166
Updated
2024/03/01
AK Scientific
Product number
5896DV
Product name
13,13,15,15-Tetradeuterio-5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene
Packaging
1mg
Price
$282
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
D37660
Product name
Varenicline-d4
Packaging
1mg
Price
$490
Updated
2021/12/16
More
Less

Varenicline-d4 Chemical Properties,Usage,Production

Description

Varenicline-d4 is intended for use as an internal standard for the quantification of varenicline by GC- or LC-MS. Varenicline is a full agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs; EC50 = 18 μM) and a partial agonist of α4β2 subunit-containing nAChRs (EC50 = 2.3 μM). Formulations containing varenicline have been used as aids in smoking cessation.

Uses

Varenicline-d4 is deuterium labeled Varenicline. Varenicline (CP 526555) is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively[1]. Varenicline is a nicotinic ligand based on the structure of cytisine, has the potential for smoking cessation treatment[2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Mihalak KB, et al. Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.Mol Pharmacol.?2006 Sep;70(3):801-5. Epub 2006 Jun 9. DOI:10.1124/mol.106.025130
[3] Bagdas D, et al. New insights on the effects of?varenicline?on nicotine reward, withdrawal and hyperalgesia in mice.Neuropharmacology.?2018 Aug;138:72-79. DOI:10.1016/j.neuropharm.2018.05.025

Varenicline-d4 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Varenicline-d4 Suppliers

China 12 India 2 United States 2 Global 16
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58

2183239-01-0, Varenicline-d4Related Search:

Varenicline Impurity 18 (+/-)-2,2,2-trifluoro-1-(4-nitro-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-ethanone Hydroxy Varenicline Varenicline Impurity 8 Varenicline Impurity 5 Hydroxy Varenicline N-Trifluoroacetate Varenicline Impurity 3 Varenicline Impurity 6 Varenicline Impurity 17 N-Methyl Varenicline 5,9-Methanoimidazo[4,5-h][3]benzazepine,1,5,6,7,8,9-hexahydro-(9CI) Varenicline-13C2,15N2 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (N-(Trifluoroacetyl)varenicline) Varenicline Impurity 13 HCl N-Acetyl Varenicline N-Formyl Varenicline 2,3,4,5-Tetrahydro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine-7,8-diamine 2,3,4,5-Tetrahydro-7,8-dinitro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine

  • Varenicline-d4
  • 7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline-7,7,9,9-d4
  • Varenicline Nitroso D4
  • D4-Varenicline
  • 2183239-01-0
  • C13H9D4N3