Kibdelone C
- Product Name
- Kibdelone C
- CAS No.
- 934464-79-6
- Chemical Name
- Kibdelone C
- Synonyms
- Kibdelone C;2H-[1]Benzopyrano[2',3':6,7]naphth[2,1-g]isoquinoline-1,14-dione, 4-chloro-6,7,10,11,12,13-hexahydro-5,10,12,13,15,16-hexahydroxy-8-methoxy-2-methyl-3-propyl-, (10S,12S,13R)-
- CBNumber
- CB02703741
- Molecular Formula
- C29H28ClNO10
- Formula Weight
- 585.99
- MOL File
- 934464-79-6.mol
Kibdelone C Property
- Melting point:
- 265-267 °C(Solv: benzene (71-43-2))
- Boiling point:
- 968.8±65.0 °C(Predicted)
- Density
- 1.71±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
- form
- A solid
- pka
- 6.44±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- 21525
- Product name
- Kibdelone C
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $285
- Updated
- 2024/03/01
- Product number
- K570518
- Product name
- KibdeloneC
- Packaging
- 2.5mg
- Price
- $475
- Updated
- 2021/12/16
Kibdelone C Chemical Properties,Usage,Production
Description
Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a panel of human tumor cell lines, and kibdelone C has low nanomolar effectiveness in these assays. Kibdelone C disrupts the actin cytoskeleton without directly binding actin or affecting its polymerization in vitro.
Uses
Kibdelone C is the major analogue of a potent antitumour complex isolated from Kibdelosporangium sp.. Structurally, kibdelone C is related to lysolipin and albofungin, however no comparative investigation of this class has been reported. The mode of action and pharmacology of the kibdelones has received little attention.
Uses
Kibdelone C is the major analogue of a potent antitumor complex isolated from Kibdelosporangium sp.. Structurally, kibdelone C is related to lysolipin and albofungin, however no comparative investigation of this class has been reported. The mode of action and pharmacology of the kibdelones has received little attention.
Uses
Kibdelone C is the major analogue of a potent antitumor complex.
References
[1] RANJALA RATNAYAKE. Kibdelones: Novel Anticancer Polyketides from a Rare Australian Actinomycete[J]. Chemistry - A European Journal, 2007, 13 5: 1610-1619. DOI: 10.1002/chem.200601236
[2] JANJIRA RUJIRAWANICH. Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives[J]. Journal of the American Chemical Society, 2016, 138 33: 10561-10570. DOI: 10.1021/jacs.6b05484
Kibdelone C Preparation Products And Raw materials
Raw materials
Preparation Products
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