HUMAN LEUKOCYTE IFN
- Product Name
- HUMAN LEUKOCYTE IFN
- CAS No.
- 284690-33-1
- Chemical Name
- HUMAN LEUKOCYTE IFN
- Synonyms
- IFL;IFN;IFNA13;α-IFN-Le;INTERFERON;HUMAN LEUKOCYTE IFN;Interferon-γ human;Interferon-γ porcine;Interferon β from rat;HUMAN LEUKOCYTE INTERFERON
- CBNumber
- CB0281625
- Formula Weight
- 0
- MOL File
- Mol file
HUMAN LEUKOCYTE IFN Property
- storage temp.
- −20°C
- form
- buffered aqueous solution
- biological source
- mouse
- CAS DataBase Reference
- 284690-33-1
N-Bromosuccinimide Price
- Product number
- SAB1412683
- Product name
- ANTI-IFNA1 antibody produced in mouse
- Purity
- purified immunoglobulin, buffered aqueous solution
- Packaging
- 50μg
- Price
- $524
- Updated
- 2024/03/01
- Product number
- I9032
- Product name
- Interferon β from mouse
- Purity
- ≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture
- Packaging
- 1VIAL
- Price
- $737
- Updated
- 2024/03/01
- Product number
- I8907
- Product name
- Interferon β from rat
- Purity
- ≥95%, recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture
- Packaging
- 1vial
- Price
- $518
- Updated
- 2024/03/01
- Product number
- CYT0000108
- Product name
- INTERFERON
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.73
- Updated
- 2021/12/16
HUMAN LEUKOCYTE IFN Chemical Properties,Usage,Production
Pharmaceutical Applications
A human protein produced by recombinant DNA technology in Escherichia coli, formulated for administration by intramuscular, subcutaneous or intralesional injection. A pegylated form, peginterferon, developed by attaching a 40 kDa branched-chain polyethylene glycol moiety to interferon- α-2a, has a prolonged half-life and is better tolerated. Potency is expressed as international units (IU), defined as the amount needed to prevent lysis of 50% of cells by vesicular stomatitis virus in tissue culture assay.
Biological Activity
In presence of virus infection, IFN β (interferon β) is upregulated and plays a crucial role in innate antiviral response. It is also important for anti-inflammatory effects.', 'Interferon β (IFN-β) suppresses a variety of proinflammatory cytokines in lymphocytes including the interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α). It also favors the synthesis of antagonists associated with interleukin IL-10 and IL-1 receptor. IFN-β downregulates interferon γ production but enhances transforming growth factor β1 expression. It has therapeutic potential in treating rheumatoid arthritis and relapsing-remitting multiple sclerosis (MS).', 'Interferon β has a role in the activation of human leukocyte antigen (HLA) gene expression. It acts as a messenger during bacterial infections.', 'Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
Mechanism of action
Although interferons are mediators of immune response, different mechanisms for the antiviral action of interferon have been proposed. Interferon-α possesses broad-spectrum antiviral activity and acts on virus-infected cells by binding to specific cell surface receptors. It inhibits the transcription and translation of mRNA into viral nucleic acid and protein. Studies in cell-free systems have shown that the addition of adenosine triphosphate and double-stranded RNA to extracts of interferon-treated cells activates cellular RNA proteins and a cellular endonuclease. This activation causes the formation of translation inhibitory protein, which terminates production of viral enzyme, nucleic acid, and structural proteins. Interferon also may act by blocking synthesis of a cleaving enzyme required for viral release.
Pharmacokinetics
Oral absorption: Poor
Cmax 3 × 106 IU intramuscularly: 20 IU/mL after 2–4 h
9 × 106 IU intramuscularly: 50–100 IU/mL after 2–4h
Plasma half-life: 3–8 h
Peginterferon: 36 h
Plasma protein binding: Not known
Cerebrospinal fluid (CSF) penetration is poor. It is not
cleared by hemodialysis. Little or none is excreted in the
urine, and its fate after release from the cell receptor is
largely unknown. The extent of excretion in breast milk is
unknown.
Clinical Use
Chronic hepatitis B
Chronic hepatitis C (in combination with ribavirin)
Condyloma acuminata (intralesional)
It may also be of benefit in hairy cell and chronic myelogenous
leukemias and Kaposi’s sarcoma.
Side effects
Toxicity has become increasingly apparent with the advent
of purer preparations. ‘Flu’-like symptoms (fever, arthralgia,
myalgia, headache, malaise, chills) occur, which can usually
be ameliorated by acetaminophen (paracetamol) administration.
Lymphocytopenia is common, generally arising 2–4 h
after administration of several million units. Liver function
test values are frequently elevated at doses above 107 IU/day.
These effects are rapidly reversible and tolerance may develop
after several doses. Other toxic effects include gastrointestinal
disturbances (anorexia, nausea, diarrhea, vomiting), weight
loss, local pain, severe fatigue, alopecia, paresthesias, confusion,
dizziness, drowsiness, nervousness and bone marrow
suppression. Neutropenia and thrombocytopenia are dose
dependent (threshold around 3 × 106 IU/day) and reversible.
Hypotension may develop during, or up to 2 days after,
treatment, and arrhythmias and cardiac failure have been
observed.
Administration of excessive doses to pregnant rhesus monkeys
in the early to mid-trimester caused abortions. Its effect
on human pregnancy is unknown. Neutralizing antibodies
have been reported in about 25% of treated patients but no
clinical sequelae to their presence have been documented.
Intralesional administration in the treatment of condylomata
acuminata is generally well tolerated.
Peginterferon is also associated with fatigue, headache,
myalgia and fever; most other side effects occur less
frequently.
HUMAN LEUKOCYTE IFN Preparation Products And Raw materials
Raw materials
Preparation Products
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