GDC-0339

Product Name: GDC-0339
CAS No.: 1428569-85-0
Chemical Name: GDC-0339
Synonyms: EOS-60554;GDC 0339,Pim,Pim kinases,inhibit,GDC0339,GDC-0339,Inhibitor;5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide;4-Thiazolecarboxamide, 5-amino-N-[5-[(4R,5R)-4-amino-5-fluorohexahydro-1H-azepin-1-yl]-1-methyl-1H-pyrazol-4-yl]-2-(2,6-difluorophenyl)-
CBNumber: CB03035403
Molecular Formula: C20H22F3N7OS
Formula Weight: 465.5
MOL File: 1428569-85-0.mol

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GDC-0339 Property

Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 52 mg/mL (111.71 mM)
form: Solid
pka: 9.28±0.40(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-4775
Product name: GDC-0339
Purity: 99.96%
Packaging: 5mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-4775
Product name: GDC-0339
Purity: 99.96%
Packaging: 10mg
Price: $800
Updated: 2021/12/16

ChemScene

Product number: CS-4775
Product name: GDC-0339
Purity: 99.96%
Packaging: 50mg
Price: $2600
Updated: 2021/12/16

ChemScene

Product number: CS-4775
Product name: GDC-0339
Purity: 99.96%
Packaging: 100mg
Price: $4500
Updated: 2021/12/16

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GDC-0339 Chemical Properties,Usage,Production

Uses

GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma[1][2].

in vivo

GDC-0339 (1-300 mg/kg; p.o; daily; for 21 days) is efficacious in RPMI8226 and MM.1S human multiple myeloma xenograft mouse models^[2].
GDC-0339 has a half-life of t1/2=0.9 h^[2].

Animal Model:	Female C.B-17 SCID mice, RPMI8226 human multiple myeloma xenograft mouse model^[2]
Dosage:	1mg/kg, 10 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg, 300 mg/kg
Administration:	Oral administration; once daily; for 21 days
Result:	Showed dose-dependent tumor growth inhibition.

IC 50

PIM1; PIM2; PIM3

References

[1] Takahashi RH, et al. CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339. Drug Metab Dispos. 2017 Oct;45(10):1084-1092. DOI:10.1124/dmd.117.076786
[2] Wang X, et al. Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma. J Med Chem. 2019 Feb 28;62(4):2140-2153. DOI:10.1021/acs.jmedchem.8b01857

GDC-0339 Preparation Products And Raw materials

Raw materials

Preparation Products

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GDC-0339 Suppliers

China 23 United States 6 Global 29

MedChemexpress LLC

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Musechem

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Aladdin Scientific

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BOC Sciences

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1428569-85-0, GDC-0339Related Search:

5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide

EOS-60554

4-Thiazolecarboxamide, 5-amino-N-[5-[(4R,5R)-4-amino-5-fluorohexahydro-1H-azepin-1-yl]-1-methyl-1H-pyrazol-4-yl]-2-(2,6-difluorophenyl)-

GDC 0339,Pim,Pim kinases,inhibit,GDC0339,GDC-0339,Inhibitor

1428569-85-0

C20H22F3N7OS