SIB 1553A hydrochloride
- Product Name
- SIB 1553A hydrochloride
- CAS No.
- 191611-89-9
- Chemical Name
- SIB 1553A hydrochloride
- Synonyms
- SIB 1553A,SIB1553A;SIB 1553A hydrochloride;SIB 1553A Hyrdrochloride;SIB 1553A hydrochloride, nAChR agonist;4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol;4-((2-(1-Methylpyrrolidin-2-yl)ethyl)thio)phenol hydrochloride;4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol:hydrochloride;(±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride
- CBNumber
- CB03037533
- Molecular Formula
- C13H20ClNOS
- Formula Weight
- 273.82
- MOL File
- 191611-89-9.mol
SIB 1553A hydrochloride Property
- Melting point:
- 149-151°C
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- DMSO (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Soluble to 100 mM in water
N-Bromosuccinimide Price
- Product number
- 14973
- Product name
- SIB 1553A (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 14973
- Product name
- SIB 1553A (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 14973
- Product name
- SIB 1553A (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $183
- Updated
- 2024/03/01
- Product number
- 14973
- Product name
- SIB 1553A (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $724
- Updated
- 2024/03/01
- Product number
- 4764
- Product name
- SIB1553Ahydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $157
- Updated
- 2021/12/16
SIB 1553A hydrochloride Chemical Properties,Usage,Production
Description
SIB 1553A is an agonist of nicotinic acetylcholine receptors (nAChRs) that displays selectivity for β4 subunit-containing receptors. Formulations containing SIB 1553A improve attentional function and performance in spatial and non-spatial working memory tasks in animals.
Uses
SIB 1553A hyrdrochloride is a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors (nAChR).
in vivo
SIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels[3].
| Animal Model: | Male Sprague-Dawley rats (200-250 g)[3] |
| Dosage: | 1, 2, 4, 10, 20 and 40 mg/kg |
| Administration: | s.c. |
| Result: | Induced hippocampal ACh release. |
References
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] J S SCHNEIDER. The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.[J]. Journal of Pharmacology and Experimental Therapeutics, 2003, 306 1: 401-406. DOI: 10.1124/jpet.103.051912
[3] TERRY A, RISBROUGH V, BUCCAFUSCO J, et al. Effects of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys.[J]. The Journal of Pharmacology and Experimental Therapeutics, 2002, 264 1: 0. DOI: 10.1124/jpet.301.1.284
SIB 1553A hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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