BC2059

Product Name: BC2059
CAS No.: 1227637-23-1
Chemical Name: BC2059
Synonyms: BC2059;Tegavivint;Tegoprazan D6;BC-2059 Te atrabetan;Tegatrabetan (BC2059);BC-2059;BC2059;TEGAVIVINT;Tegatrabetan, 10 mM in DMSO;Tegatrabetan (BC-2059) ，S0733;TEGATRABETAN;BC-2059;TEGAVIVINT;Tegatrabetan,inhibit,Inhibitor,β-catenin,BC-2059,Beta catenin,BC 2059
CBNumber: CB03038499
Molecular Formula: C28H36N4O6S2
Formula Weight: 588.74
MOL File: 1227637-23-1.mol

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BC2059 Property

Boiling point:: 757.6±70.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: 125 mg/mL (212.32 mM)
pka: 10.07±0.20(Predicted)
form: Solid
color: White to light yellow
InChIKey: LQQUOMJXUXVPRB-IOTKHNBZSA-N
SMILES: [S](=O)(=O)(N5C[C@H](C[C@H](C5)C)C)c1cc2c(cc1)C(c3c(cc(cc3)[S](=O)(=O)N4C[C@H](C[C@H](C4)C)C)C2N=O)N=O

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0039507
Product name: Tegatrabetan
Purity: 98.19%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0039507
Product name: Tegatrabetan
Purity: 98.19%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0039507
Product name: Tegatrabetan
Purity: 98.19%
Packaging: 50mg
Price: $430
Updated: 2021/12/16

DC Chemicals

Product number: DC20756
Product name: Tegatrabetan
Purity: >98%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

DC Chemicals

Product number: DC20756
Product name: Tegatrabetan
Purity: >98%
Packaging: 1g
Price: $2500
Updated: 2021/12/16

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BC2059 Chemical Properties,Usage,Production

Uses

Tegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1)[1].

Biological Activity

Tegatrabetan (BC2059) is a beta-Catenin antagonist. It disrupts β-catenin binding to scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and reduces β-catenin nuclear levels.

in vivo

Tegatrabetan (BC2059; 1.0 or 5.0 mg/kg/day; intravenously) significantly improves the median survival of the mice from approximately 17.5 to 39 days. Treatment with Tegatrabetan (10 mg/kg/day; intravenously) alone further improves the median survival to 51.5 days.

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Animal Model:	NOD/SCID mice bearing OCI-AML3 xenografts
Dosage:	1 mg/kg; 5 mg/kg; 10 mg/kg
Administration:	Intravenously; 1 mg/kg daily 4 days per week or 5 mg/kg or 10 mg/kg of BC2059 twice per week (Tuesday and Thursday) for 3 weeks.
Result:	Treatment significantly improved survival of NOD/SCID mice bearing OCI-AML3 xenografts.

target

Target	Value
β-catenin ()

References

[1] Fiskus W, et al. Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells. Leukemia. 2015 Jun;29(6):1267-78. DOI:10.1038/leu.2014.340

BC2059 Preparation Products And Raw materials

Raw materials

Preparation Products

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BC2059 Suppliers

China 41 India 1 United States 6 Global 48

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777;
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
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BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
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Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4797
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
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Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9353
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Jiangsu aikang biomedical research and development co., LTD

Tel: 025-58859352 13155353615
Email: qzhang@aikonchem.com
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
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1227637-23-1, BC2059Related Search:

BC2059

BC-2059;BC2059;TEGAVIVINT

Tegavivint

TEGATRABETAN;BC-2059;TEGAVIVINT

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rel-2,7-Bis(((3R,5S)-3,5-dimethylpiperidin-1-yl)sulfonyl)anthracene-9,10-dione dioxime

Tegatrabetan (BC2059)

Tegatrabetan,inhibit,Inhibitor,β-catenin,BC-2059,Beta catenin,BC 2059

Tegoprazan D6

BC-2059 Te atrabetan

Tegatrabetan, 10 mM in DMSO

Tegatrabetan (BC-2059) ，S0733

1227637-23-1