ChemicalBook > CAS DataBase List > BC2059
BC2059
- Product Name
- BC2059
- CAS No.
- 1227637-23-1
- Chemical Name
- BC2059
- Synonyms
- BC2059;Tegavivint;Tegoprazan D6;BC-2059 Te atrabetan;Tegatrabetan (BC2059);BC-2059;BC2059;TEGAVIVINT;TEGATRABETAN;BC-2059;TEGAVIVINT;Tegatrabetan,inhibit,Inhibitor,β-catenin,BC-2059,Beta catenin,BC 2059;rel-2,7-Bis(((3R,5S)-3,5-dimethylpiperidin-1-yl)sulfonyl)anthracene-9,10-dione dioxime;9,10-Anthracenedione, 2,7-bis[[(3R,5S)-3,5-dimethyl-1-piperidinyl]sulfonyl]-, 9,10-dioxime, rel-
- CBNumber
- CB03038499
- Molecular Formula
- C28H36N4O6S2
- Formula Weight
- 588.74
- MOL File
- 1227637-23-1.mol
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BC2059 Property
- Boiling point:
- 757.6±70.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO: 125 mg/mL (212.32 mM)
- pka
- 10.07±0.20(Predicted)
- form
- Solid
- color
- White to light yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0039507
- Product name
- Tegatrabetan
- Purity
- 98.19%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0039507
- Product name
- Tegatrabetan
- Purity
- 98.19%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0039507
- Product name
- Tegatrabetan
- Purity
- 98.19%
- Packaging
- 50mg
- Price
- $430
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC20756
- Product name
- Tegatrabetan
- Purity
- >98%
- Packaging
- 100mg
- Price
- $650
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC20756
- Product name
- Tegatrabetan
- Purity
- >98%
- Packaging
- 1g
- Price
- $2500
- Updated
- 2021/12/16
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BC2059 Chemical Properties,Usage,Production
Biological Activity
Tegatrabetan (BC2059) is a beta-Catenin antagonist. It disrupts β-catenin binding to scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and reduces β-catenin nuclear levels.
in vivo
Tegatrabetan (BC2059; 1.0 or 5.0 mg/kg/day; intravenously) significantly improves the median survival of the mice from approximately 17.5 to 39 days. Treatment with Tegatrabetan (10 mg/kg/day; intravenously) alone further improves the median survival to 51.5 days.
| Animal Model: | NOD/SCID mice bearing OCI-AML3 xenografts | < /tr>
| Dosage: | 1 mg/kg; 5 mg/kg; 10 mg/kg |
| Administration: | Intravenously; 1 mg/kg daily 4 days per week or 5 mg/kg or 10 mg/kg of BC2059 twice per week (Tuesday and Thursday) for 3 weeks. |
| Result: | Treatment significantly improved survival of NOD/SCID mice bearing OCI-AML3 xenografts. |
target
| Target | Value |
| β-catenin () |
BC2059 Preparation Products And Raw materials
Raw materials
Preparation Products
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