SID 3712249

Product Name: SID 3712249
CAS No.: 522606-67-3
Chemical Name: SID 3712249
Synonyms: SID 3712249;miR544-IN-1;MiR-544 Inhibitor 1;SID 3712249 >=95% (HPLC);1,8-diamino-3,6-di(1-pyrrolidinyl)[2,7]naphthyridine-4-carbonitrile;2,7-Naphthyridine-4-carbonitrile, 1,8-diamino-3,6-di-1-pyrrolidinyl-
CBNumber: CB03121133
Molecular Formula: C17H21N7
Formula Weight: 323.4
MOL File: 522606-67-3.mol

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SID 3712249 Property

Boiling point:: 669.0±55.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
form: A crystalline solid
pka: 8.83±0.30(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1518
Product name: SID 3712249
Purity: ≥95% (HPLC)
Packaging: 5 mg
Price: $111
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1518
Product name: SID 3712249
Purity: ≥95% (HPLC)
Packaging: 25 mg
Price: $340
Updated: 2025/07/31

Cayman Chemical

Product number: 29723
Product name: SID 3712249
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29723
Product name: SID 3712249
Packaging: 50mg
Price: $638
Updated: 2024/03/01

Cayman Chemical

Product number: 29723
Product name: SID 3712249
Packaging: 10mg
Price: $176
Updated: 2024/03/01

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SID 3712249 Chemical Properties,Usage,Production

Uses

SID 3712249 (MiR-544 Inhibitor 1) is a miR-544 biogenesis inhibitor. SID 3712249 binds directly to the precursor miRNA. SID 3712249 blocks production of the mature microRNA and decreases miR-544, HIF-1α, and ATM transcripts. SID 3712249 can be used in the research of cancers, such as breast cancer[1].

Biological Activity

SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2μ-O-methyl RNA antagomir.

in vivo

SID 3712249 (compound 1, 100 μL of 40 μM, intraperitoneal injection) inhibited tumor growth in MDA-MB-231-GFP-luc tumor model^[1].
SID 3712249 (20 nM, pre-treated GFP-labeled MDA-MB-231 cells, intraperitoneal injection) inhibited tumor growth in MDA-MB-231-GFP-luc tumor model^[1].

Animal Model:	MDA-MB-231-GFP-luc tumor model^[1]
Dosage:	100 μL of 40 μM
Administration:	Intraperitoneal injection
Result:	Inhibited tumor growth (evidenced by live animal bioluminescent imaging) with no overt side effects. Decreased levels of miR-544, ATM, and HIF-1α and increased levels of mTOR (resected tumor samples).

References

[1] Christopher L Haga, et al. Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling. ACS Chem Biol. 2015 Oct 16;10(10):2267-76. DOI:10.1021/acschembio.5b00265

SID 3712249 Preparation Products And Raw materials

Raw materials

Preparation Products

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SID 3712249 Suppliers

China 30 United States 6 Global 36

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522606-67-3, SID 3712249Related Search:

miR544-IN-1

SID 3712249

1,8-diamino-3,6-di(1-pyrrolidinyl)[2,7]naphthyridine-4-carbonitrile

MiR-544 Inhibitor 1

2,7-Naphthyridine-4-carbonitrile, 1,8-diamino-3,6-di-1-pyrrolidinyl-

SID 3712249 >=95% (HPLC)

522606-67-3