ChemicalBook > CAS DataBase List > N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide

N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide

Product Name
N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide
CAS No.
1124381-43-6
Chemical Name
N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide
Synonyms
MSC-2032964A;MSC 2032964A, 10 mM in DMSO;N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide;N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide;3-Pyridinecarboxamide, N-[5-(cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-
CBNumber
CB03133736
Molecular Formula
C16H13F3N6O
Formula Weight
362.3092296
MOL File
1124381-43-6.mol
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N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide Property

Density 
1.63±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
5.36±0.30(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
5641
Product name
MSC2032964A
Purity
≥98%(HPLC)
Packaging
10
Price
$221
Updated
2021/12/16
Tocris
Product number
5641
Product name
MSC2032964A
Purity
≥98%(HPLC)
Packaging
50
Price
$864
Updated
2021/12/16
TRC
Product number
M755400
Product name
MSC2032964A
Packaging
5mg
Price
$115
Updated
2021/12/16
TRC
Product number
M755400
Product name
MSC2032964A
Packaging
10mg
Price
$185
Updated
2021/12/16
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N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide Chemical Properties,Usage,Production

Uses

MSC 2032964A acts as a selective ASK1 inhibitor suppressing neuroinflammation in mice.

in vivo

MSC 2032964A (5 mg/kg, p.o.) exhibits an oral bioavailability of 82%, a clearance of 1.1 L/kg/ h, a half-life of 5.2 h and a volume of distribution Vss of 1.0 L/kg in SPrague Dawley rats[1].
MSC 2032964A (30 mg/kg, p.o., once daily for 40 days) attenuates neurological symptoms in both spinal cord and optic nerve lesions, and thus ameliorates the MOG (35-55) (HY-P1240)-induced autoimmune encephalomyelitis in C57BL/6J mice model[1].

Animal Model:MOG (35-55)-induced autoimmune encephalomyelitis in C57BL/6J mice[1]
Dosage:30 mg/kg
Administration:p.o., once daily for 40 days
Result:Reduced demyelination in optic nerve, decreased astrocyte and microglia activation in spinal cord.

IC 50

ASK1: 96 nM (IC50)

storage

Store at -20°C

N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide Suppliers

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1124381-43-6, N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamideRelated Search:


  • N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide
  • MSC-2032964A
  • N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide
  • 3-Pyridinecarboxamide, N-[5-(cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-
  • MSC 2032964A, 10 mM in DMSO
  • 1124381-43-6