MK-2 Inhibitor III
- Product Name
- MK-2 Inhibitor III
- CAS No.
- 1186648-22-5
- Chemical Name
- MK-2 Inhibitor III
- Synonyms
- MK2-IN-3 hydrate;MK-2 Inhibitor III;MK-2 INHIBITOR III (COMPOUND 16);MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem;2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one:hydrate;2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate;Inhibitor,MAP kinase activated protein kinase 2,inhibit,MK2 IN 3 hydrate,MAPKAP kinase 2,MK-2-IN-3 hydrate,MAPK activated protein kinase 2,MK2IN3 hydrate,MAPKAPK2 (MK2),Mitogen-activated protein kinase activated protein kinase 2
- CBNumber
- CB03136757
- Molecular Formula
- C21H18N4O2
- Formula Weight
- 358.4
- MOL File
- 1186648-22-5.mol
MK-2 Inhibitor III Property
- Melting point:
- >255°C (dec.)
- storage temp.
- +2C to +8C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Pale yellow solid
- color
- Off-White to Pale Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 15943
- Product name
- MK2 Inhibitor III
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 15943
- Product name
- MK2 Inhibitor III
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 15943
- Product name
- MK2 Inhibitor III
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $225
- Updated
- 2024/03/01
- Product number
- 3003DC
- Product name
- MK-2InhibitorIII
- Packaging
- 5mg
- Price
- $348
- Updated
- 2021/12/16
- Product number
- 47746
- Product name
- MK2InhibitorIII
- Packaging
- 2.5mg
- Price
- $625
- Updated
- 2021/12/16
MK-2 Inhibitor III Chemical Properties,Usage,Production
Description
MAP kinase-
Uses
MAP kinase-activated protein kinase 2 (MAPKAP2, MK2) is a stress-activated serine/threonine protein kinase that is phosphorylated by p38 MAP kinase and is involved in diverse cellular functions with a central role in inflammation. MK2 inhibitor III is a potent, cell-permeable inhibitor of MK2 (IC50 = 8.5 nM). It less potently blocks MK3 and MK5 (IC50s = 210 and 81 nM, respectively) and is weak or inactive against several other kinases, including other p38 MAP kinase targets. MK2 inhibitor III prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells (IC50 = 4.4 μM).[Cayman Chemical]