ChemicalBook > CAS DataBase List > (S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
(S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
- Product Name
- (S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
- CAS No.
- 1815613-42-3
- Chemical Name
- (S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine
- Synonyms
- LX-9211;EOS-61829;BMS-986176;Pilavapadin;BMS-986176 ，E0498;BMS-986176( LX-9211);BMS-986176, 10 mM in DMSO;(S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine;(2S)-1-{[2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl]oxy}-2,4-dimethylpentan-2-amine;2-Pentanamine, 1-[[2',6-bis(difluoromethyl)[2,4'-bipyridin]-5-yl]oxy]-2,4-dimethyl-, (2S)-
- CBNumber
- CB03142383
- Molecular Formula
- C19H23F4N3O
- Formula Weight
- 385.4
- MOL File
- 1815613-42-3.mol
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(S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine Property
- Boiling point:
- 470.8±45.0 °C(Predicted)
- Density
- 1.188±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO : 220 mg/mL (570.84 mM; Need ultrasonic)
- form
- Solid
- pka
- 9.23±0.10(Predicted)
- color
- Off-white to light yellow
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(S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine Chemical Properties,Usage,Production
Uses
BMS-986176 (LX-9211) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2 nM. BMS-986176 can be used for neurodegenerative diseases research[1].
References
[1] Guanglin Luo, et al. Biaryl kinase inhibitors. WO2015153720A1.
[2] Guanglin Luo, et al. Discovery of ( S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain. J Med Chem. 2022 Mar 24;65(6):4457-4480. DOI:10.1021/acs.jmedchem.1c02131
(S)-1-((2',6-bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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