ChemicalBook > CAS DataBase List > MT-DADMe-ImmA

MT-DADMe-ImmA

Product Name
MT-DADMe-ImmA
CAS No.
653592-04-2
Chemical Name
MT-DADMe-ImmA
Synonyms
MTDIA;MT-DADMe-ImmA HCl;MT-DADMe-ImmA, 10 mM in DMSO;Methylthio-DADMe-Immucillin A;METHYLTHIO-DADME-IMMUCILLIN A; MTDIA;MTDADMeImmA,inhibit,MT DADMe ImmA,Inhibitor;MT-DADMe-ImmA (Methylthio-DADMe-Immucillin A;MTDIA; MTDIA HCL; METHYLTHIO-DADME-IMMUCILLIN A; MT-DADME-IMMA; MT-DADME-IMMA HCL;(3R,4S)-1-((4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((methylthio)methyl)pyrrolidin-3-ol;3-Pyrrolidinol, 1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylthio)methyl]-, (3R,4S)-
CBNumber
CB03164833
Molecular Formula
C13H19N5OS
Formula Weight
293.39
MOL File
653592-04-2.mol
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MT-DADMe-ImmA Property

Melting point:
108-110 °C
Boiling point:
566.1±50.0 °C(Predicted)
Density 
1.412±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
form 
A crystalline solid
pka
14.13±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29711
Product name
MT-DADMe-ImmA
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
29711
Product name
MT-DADMe-ImmA
Packaging
25mg
Price
$704
Updated
2024/03/01
Cayman Chemical
Product number
29711
Product name
MT-DADMe-ImmA
Packaging
5mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
29711
Product name
MT-DADMe-ImmA
Packaging
10mg
Price
$301
Updated
2024/03/01
DC Chemicals
Product number
DC10332
Product name
MT-DADMe-ImmA
Purity
>98%
Packaging
100mg
Price
$700
Updated
2021/12/16
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MT-DADMe-ImmA Chemical Properties,Usage,Production

Description

MT-DADMe-ImmA is an inhibitor of 5''-methylthioadenosine phosphorylase (MTAP; Ki = 1.7 nM). It increases levels of MTA , a product of polyamine metabolism, in FaDu human squamous cell carcinoma cells when used at a concentration of 1 μM. MT-DADMe-ImmA (5, 9, and 21 mg/kg per day for 28 days) reduces tumor growth in a FaDu mouse xenograft model.

Uses

MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM.

in vivo

The t1/2 for onset of inhibition is 50 min with complete inhibition by 250 min. MTAP activity slowly returns, giving a biological half-life for the action of oral MT-DADMe-ImmA of 6.3 days. The time-dependent growth of FaDu tumors in immunodeficient mice is suppressed by oral or intraperitoneal treatment with MT-DADMe-ImmA[2].

References

[1] Evans GB, et al. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem. 2005 Jul 14;48(14):4679-89. DOI:10.1021/jm050269z
[2] Basu I, et al. A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. J Biol Chem. 2007 Jul 20;282(29):21477-86. DOI:10.1074/jbc.M702287200

MT-DADMe-ImmA Preparation Products And Raw materials

Raw materials

Preparation Products

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MT-DADMe-ImmA Suppliers

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653592-04-2, MT-DADMe-ImmARelated Search:


  • MT-DADMe-ImmA HCl
  • MTDIA; MTDIA HCL; METHYLTHIO-DADME-IMMUCILLIN A; MT-DADME-IMMA; MT-DADME-IMMA HCL
  • Methylthio-DADMe-Immucillin A
  • METHYLTHIO-DADME-IMMUCILLIN A; MTDIA
  • MTDIA
  • 3-Pyrrolidinol, 1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylthio)methyl]-, (3R,4S)-
  • (3R,4S)-1-((4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((methylthio)methyl)pyrrolidin-3-ol
  • MTDADMeImmA,inhibit,MT DADMe ImmA,Inhibitor
  • MT-DADMe-ImmA, 10 mM in DMSO
  • MT-DADMe-ImmA (Methylthio-DADMe-Immucillin A
  • 653592-04-2