MT-DADMe-ImmA
- Product Name
- MT-DADMe-ImmA
- CAS No.
- 653592-04-2
- Chemical Name
- MT-DADMe-ImmA
- Synonyms
- MTDIA;MT-DADMe-ImmA HCl;MT-DADMe-ImmA, 10 mM in DMSO;Methylthio-DADMe-Immucillin A;METHYLTHIO-DADME-IMMUCILLIN A; MTDIA;MTDADMeImmA,inhibit,MT DADMe ImmA,Inhibitor;MT-DADMe-ImmA (Methylthio-DADMe-Immucillin A;MTDIA; MTDIA HCL; METHYLTHIO-DADME-IMMUCILLIN A; MT-DADME-IMMA; MT-DADME-IMMA HCL;(3R,4S)-1-((4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((methylthio)methyl)pyrrolidin-3-ol;3-Pyrrolidinol, 1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylthio)methyl]-, (3R,4S)-
- CBNumber
- CB03164833
- Molecular Formula
- C13H19N5OS
- Formula Weight
- 293.39
- MOL File
- 653592-04-2.mol
MT-DADMe-ImmA Property
- Melting point:
- 108-110 °C
- Boiling point:
- 566.1±50.0 °C(Predicted)
- Density
- 1.412±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
- form
- A crystalline solid
- pka
- 14.13±0.40(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 29711
- Product name
- MT-DADMe-ImmA
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 29711
- Product name
- MT-DADMe-ImmA
- Packaging
- 25mg
- Price
- $704
- Updated
- 2024/03/01
- Product number
- 29711
- Product name
- MT-DADMe-ImmA
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 29711
- Product name
- MT-DADMe-ImmA
- Packaging
- 10mg
- Price
- $301
- Updated
- 2024/03/01
- Product number
- DC10332
- Product name
- MT-DADMe-ImmA
- Purity
- >98%
- Packaging
- 100mg
- Price
- $700
- Updated
- 2021/12/16
MT-DADMe-ImmA Chemical Properties,Usage,Production
Description
MT-DADMe-ImmA is an inhibitor of 5''-methylthioadenosine phosphorylase (MTAP; Ki = 1.7 nM). It increases levels of MTA , a product of polyamine metabolism, in FaDu human squamous cell carcinoma cells when used at a concentration of 1 μM. MT-DADMe-ImmA (5, 9, and 21 mg/kg per day for 28 days) reduces tumor growth in a FaDu mouse xenograft model.
Uses
MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM.
in vivo
The t1/2 for onset of inhibition is 50 min with complete inhibition by 250 min. MTAP activity slowly returns, giving a biological half-life for the action of oral MT-DADMe-ImmA of 6.3 days. The time-dependent growth of FaDu tumors in immunodeficient mice is suppressed by oral or intraperitoneal treatment with MT-DADMe-ImmA[2].
References
[1] Evans GB, et al. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem. 2005 Jul 14;48(14):4679-89. DOI:10.1021/jm050269z
[2] Basu I, et al. A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. J Biol Chem. 2007 Jul 20;282(29):21477-86. DOI:10.1074/jbc.M702287200
MT-DADMe-ImmA Preparation Products And Raw materials
Raw materials
Preparation Products
MT-DADMe-ImmA Suppliers
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19552
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58