ChemicalBook > CAS DataBase List > CU CPT 4a

CU CPT 4a

Product Name: CU CPT 4a
CAS No.: 1279713-77-7
Chemical Name: CU CPT 4a
Synonyms: TLR3-IN-1;CU CPT 4a;TLR3-IN-1, 10 mM in DMSO;(3-Chloro-6-fluorobenzo[b]thiophene-2-carbonyl)-D-phenylalanine;N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine;D-Phenylalanine, N-[(3-chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-;TLR3/dsRNA complex,inhibit,CU-CPT 4a,TNF-α,protein-RNA interaction,IL-1β,TLR-3-IN-1,Inhibitor,TLR3 IN 1,TLR3IN1,Toll-like Receptor (TLR)
CBNumber: CB03310333
Molecular Formula: C18H13ClFNO3S
Formula Weight: 377.82
MOL File: 1279713-77-7.mol

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CU CPT 4a Property

storage temp.: Store at 4°C
solubility: <37.78mg/ml in DMSO
form: solid
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 4883
Product name: CUCPT4a
Purity: ≥98%(HPLC)
Packaging: 10
Price: $233
Updated: 2021/12/16

Tocris

Product number: 4883
Product name: CUCPT4a
Purity: ≥98%(HPLC)
Packaging: 50
Price: $969
Updated: 2021/12/16

TRC

Product number: C852005
Product name: CUCPT4a
Packaging: 1mg
Price: $115
Updated: 2021/12/16

ApexBio Technology

Product number: B5752
Product name: CUCPT4a
Packaging: 50mg
Price: $1410
Updated: 2021/12/16

AK Scientific

Product number: 4329DK
Product name: CUCPT4a
Packaging: 1mg
Price: $241
Updated: 2021/12/16

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CU CPT 4a Chemical Properties,Usage,Production

Uses

CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β[1].

Biological Activity

cu cpt 4a is a selective tlr3 inhibitor with ic50 of 3.44 μm in raw 264.7 cells. it can inhibit tlr3/dsrna complex-mediated downstream signaling pathways and inhibit the production of tnf-α and il-1β in whole cells. it reduces the mortality of crypt cells in mice and reduces gastrointestinal syndrome.[1]. cheng k, wang x, yin h. small-molecule inhibitors of the tlr3/dsrna complex. journal of the american chemical society, 2011, 133(11): 3764-3767.[2]. blockade of tlr3 protects mice from lethal radiation-induced gastrointestinal syndrome. nature communications, 2014, 5.

IC 50

TLR3: 3.44 μM (IC₅₀, in RAW 264.7 cells)

storage

Store at +4°C

References

[1] Yibo Wang, et al. Small-Molecule Modulators of Toll-like Receptors. Acc Chem Res. 2020 May 19;53(5):1046-1055. DOI:10.1021/acs.accounts.9b00631

CU CPT 4a Preparation Products And Raw materials

Raw materials

Preparation Products

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CU CPT 4a Suppliers

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1279713-77-7, CU CPT 4aRelated Search:

CU CPT 4a

N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine

D-Phenylalanine, N-[(3-chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-

TLR3-IN-1

TLR3/dsRNA complex,inhibit,CU-CPT 4a,TNF-α,protein-RNA interaction,IL-1β,TLR-3-IN-1,Inhibitor,TLR3 IN 1,TLR3IN1,Toll-like Receptor (TLR)

(3-Chloro-6-fluorobenzo[b]thiophene-2-carbonyl)-D-phenylalanine

TLR3-IN-1, 10 mM in DMSO

1279713-77-7