CU CPT 4a
- Product Name
- CU CPT 4a
- CAS No.
- 1279713-77-7
- Chemical Name
- CU CPT 4a
- Synonyms
- TLR3-IN-1;CU CPT 4a;TLR3-IN-1, 10 mM in DMSO;(3-Chloro-6-fluorobenzo[b]thiophene-2-carbonyl)-D-phenylalanine;N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine;D-Phenylalanine, N-[(3-chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-;TLR3/dsRNA complex,inhibit,CU-CPT 4a,TNF-α,protein-RNA interaction,IL-1β,TLR-3-IN-1,Inhibitor,TLR3 IN 1,TLR3IN1,Toll-like Receptor (TLR)
- CBNumber
- CB03310333
- Molecular Formula
- C18H13ClFNO3S
- Formula Weight
- 377.82
- MOL File
- 1279713-77-7.mol
CU CPT 4a Property
- storage temp.
- Store at 4°C
- solubility
- <37.78mg/ml in DMSO
- form
- solid
- color
- White
N-Bromosuccinimide Price
- Product number
- 4883
- Product name
- CUCPT4a
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $233
- Updated
- 2021/12/16
- Product number
- 4883
- Product name
- CUCPT4a
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $969
- Updated
- 2021/12/16
- Product number
- C852005
- Product name
- CUCPT4a
- Packaging
- 1mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- B5752
- Product name
- CUCPT4a
- Packaging
- 50mg
- Price
- $1410
- Updated
- 2021/12/16
- Product number
- 4329DK
- Product name
- CUCPT4a
- Packaging
- 1mg
- Price
- $241
- Updated
- 2021/12/16
CU CPT 4a Chemical Properties,Usage,Production
Uses
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β[1].
Biological Activity
cu cpt 4a is a selective tlr3 inhibitor with ic50 of 3.44 μm in raw 264.7 cells. it can inhibit tlr3/dsrna complex-mediated downstream signaling pathways and inhibit the production of tnf-α and il-1β in whole cells. it reduces the mortality of crypt cells in mice and reduces gastrointestinal syndrome.[1]. cheng k, wang x, yin h. small-molecule inhibitors of the tlr3/dsrna complex. journal of the american chemical society, 2011, 133(11): 3764-3767.[2]. blockade of tlr3 protects mice from lethal radiation-induced gastrointestinal syndrome. nature communications, 2014, 5.
IC 50
TLR3: 3.44 μM (IC50, in RAW 264.7 cells)
storage
Store at +4°C
References
[1] Yibo Wang, et al. Small-Molecule Modulators of Toll-like Receptors. Acc Chem Res. 2020 May 19;53(5):1046-1055. DOI:10.1021/acs.accounts.9b00631
CU CPT 4a Preparation Products And Raw materials
Raw materials
Preparation Products
CU CPT 4a Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77