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CU CPT 4a

Product Name
CU CPT 4a
CAS No.
1279713-77-7
Chemical Name
CU CPT 4a
Synonyms
TLR3-IN-1;CU CPT 4a;TLR3-IN-1, 10 mM in DMSO;(3-Chloro-6-fluorobenzo[b]thiophene-2-carbonyl)-D-phenylalanine;N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine;D-Phenylalanine, N-[(3-chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-;TLR3/dsRNA complex,inhibit,CU-CPT 4a,TNF-α,protein-RNA interaction,IL-1β,TLR-3-IN-1,Inhibitor,TLR3 IN 1,TLR3IN1,Toll-like Receptor (TLR)
CBNumber
CB03310333
Molecular Formula
C18H13ClFNO3S
Formula Weight
377.82
MOL File
1279713-77-7.mol
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CU CPT 4a Property

storage temp. 
Store at 4°C
solubility 
<37.78mg/ml in DMSO
form 
solid
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4883
Product name
CUCPT4a
Purity
≥98%(HPLC)
Packaging
10
Price
$233
Updated
2021/12/16
Tocris
Product number
4883
Product name
CUCPT4a
Purity
≥98%(HPLC)
Packaging
50
Price
$969
Updated
2021/12/16
TRC
Product number
C852005
Product name
CUCPT4a
Packaging
1mg
Price
$115
Updated
2021/12/16
ApexBio Technology
Product number
B5752
Product name
CUCPT4a
Packaging
50mg
Price
$1410
Updated
2021/12/16
AK Scientific
Product number
4329DK
Product name
CUCPT4a
Packaging
1mg
Price
$241
Updated
2021/12/16
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CU CPT 4a Chemical Properties,Usage,Production

Uses

CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β[1].

Biological Activity

cu cpt 4a is a selective tlr3 inhibitor with ic50 of 3.44 μm in raw 264.7 cells. it can inhibit tlr3/dsrna complex-mediated downstream signaling pathways and inhibit the production of tnf-α and il-1β in whole cells. it reduces the mortality of crypt cells in mice and reduces gastrointestinal syndrome.[1]. cheng k, wang x, yin h. small-molecule inhibitors of the tlr3/dsrna complex. journal of the american chemical society, 2011, 133(11): 3764-3767.[2]. blockade of tlr3 protects mice from lethal radiation-induced gastrointestinal syndrome. nature communications, 2014, 5.

IC 50

TLR3: 3.44 μM (IC50, in RAW 264.7 cells)

storage

Store at +4°C

References

[1] Yibo Wang, et al. Small-Molecule Modulators of Toll-like Receptors. Acc Chem Res. 2020 May 19;53(5):1046-1055. DOI:10.1021/acs.accounts.9b00631

CU CPT 4a Preparation Products And Raw materials

Raw materials

Preparation Products

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CU CPT 4a Suppliers

China 40 United Kingdom 1 United States 6 Global 47
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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Aladdin Scientific
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Email
tp@aladdinsci.com
Country
United States
ProdList
57505
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58
ApexBio Technology
Tel
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sales@apexbt.com
Country
United States
ProdList
6251
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58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
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65
Cayman Chemical Company
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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United States Biological
Tel
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80

1279713-77-7, CU CPT 4aRelated Search:


  • CU CPT 4a
  • N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine
  • D-Phenylalanine, N-[(3-chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-
  • TLR3-IN-1
  • TLR3/dsRNA complex,inhibit,CU-CPT 4a,TNF-α,protein-RNA interaction,IL-1β,TLR-3-IN-1,Inhibitor,TLR3 IN 1,TLR3IN1,Toll-like Receptor (TLR)
  • (3-Chloro-6-fluorobenzo[b]thiophene-2-carbonyl)-D-phenylalanine
  • TLR3-IN-1, 10 mM in DMSO
  • 1279713-77-7