ChemicalBook > CAS DataBase List > 1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride

1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride

Product Name
1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride
CAS No.
1620278-72-9
Chemical Name
1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride
Synonyms
TLR7/8 agonist-5d;TLR7/8 agonist 1 2HCl;8 agonist 1 dihydrochloride;TLR7/8 Agonist 1 (hydrochloride);TLR7/8 Agonist 5d (hydrochloride);TLR7/8 agonist 1 (dihydrochloride);TLR7/8 agonist 1 dihydrochloride, 10 mM in DMSO;1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride;Toll-like Receptor (TLR),TLR7/8 agonist 1,TLR7/8 agonist 1 dihydrochloride,TLR-7/8 agonist 1 dihydrochloride,Inhibitor,inhibit
CBNumber
CB03374339
Molecular Formula
C22H26ClN5
Formula Weight
395.94
MOL File
1620278-72-9.mol
More
Less

1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMSO:83.33(Max Conc. mg/mL);192.72(Max Conc. mM)
form 
A solid
color 
Off-white to light yellow
InChI
InChI=1S/C22H25N5.ClH/c1-2-3-8-19-26-20-21(17-6-4-5-7-18(17)25-22(20)24)27(19)14-16-11-9-15(13-23)10-12-16;/h4-7,9-12H,2-3,8,13-14,23H2,1H3,(H2,24,25);1H
InChIKey
IIFIHBPSMOIXGG-UHFFFAOYSA-N
SMILES
C(C1C=CC(CN)=CC=1)N1C(=NC2C(N)=NC3=CC=CC=C3C1=2)CCCC.Cl
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
28451
Product name
TLR7/8 Agonist 1 (hydrochloride)
Packaging
500μg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
28451
Product name
TLR7/8 Agonist 1 (hydrochloride)
Packaging
5mg
Price
$468
Updated
2024/03/01
Cayman Chemical
Product number
28451
Product name
TLR7/8 Agonist 1 (hydrochloride)
Packaging
1mg
Price
$131
Updated
2024/03/01
AK Scientific
Product number
3353EB
Product name
TLR7/8agonist1(dihydrochloride)
Packaging
1mg
Price
$243
Updated
2021/12/16
ChemScene
Product number
CS-0032947
Product name
TLR7/8agonist1(dihydrochloride)
Purity
98.47%
Packaging
10mg
Price
$550
Updated
2021/12/16
More
Less

1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride Chemical Properties,Usage,Production

Biological Activity

TLR7/8 agonist 1 dihydrochloride is a dual agonist of the toll-like receptor TLR7/TLR8.

in vitro

TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity.It retains TLR7- agonistic activity with an EC 50 of 20 nM. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens.

target

TLR7/TLR8

1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride Suppliers

China 63 United States 4 Global 67
Nanjing Qishi Biotechnology Co. Ltd.
Tel
19822610310
Email
3122922726@qq.com
Country
China
ProdList
114
Advantage
58
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
40000
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4810
Advantage
55
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
Tel
0431-80534353 19917294565
Email
et@chemextension.com
Country
China
ProdList
3828
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71615
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9024
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29662
Advantage
68
Zhengzhou Huiju Chemical Co., Ltd.
Tel
0371-55900031 18137872243
Email
3927209986@qq.com
Country
China
ProdList
10000
Advantage
55

1620278-72-9, 1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochlorideRelated Search:


  • 1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride
  • TLR7/8 agonist 1 (dihydrochloride)
  • TLR7/8 agonist-5d
  • TLR7/8 Agonist 1 (hydrochloride)
  • 8 agonist 1 dihydrochloride
  • TLR7/8 Agonist 5d (hydrochloride)
  • Toll-like Receptor (TLR),TLR7/8 agonist 1,TLR7/8 agonist 1 dihydrochloride,TLR-7/8 agonist 1 dihydrochloride,Inhibitor,inhibit
  • TLR7/8 agonist 1 2HCl
  • TLR7/8 agonist 1 dihydrochloride, 10 mM in DMSO
  • 1620278-72-9