ANISOTROPINE METHYLBROMIDE

Product Name: ANISOTROPINE METHYLBROMIDE
CAS No.: 80-50-2
Chemical Name: ANISOTROPINE METHYLBROMIDE
Synonyms: Vapin;C06830;valpin;endo-id;Valpin 50;endo-omid;lytispasm;Octatropine;Anisotropinmethylbromid;Octatropine metylbromide
CBNumber: CB0341288
Molecular Formula: C17H32NO2.Br
Formula Weight: 362.35
MOL File: 80-50-2.mol

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ANISOTROPINE METHYLBROMIDE Property

Melting point:: 329°
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White

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Safety

Hazard Codes: Xn,N
Risk Statements: 20/21/22-50/53
Safety Statements: 36-61-60
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
RTECS: YM3710000
HazardClass: 9
Hazardous Substances Data: 80-50-2(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A5181
Product name: Anisotropine methyl bromide
Packaging: 5g
Price: $137
Updated: 2025/07/31

TRC

Product number: A673960
Product name: Anisotropine methyl bromide
Packaging: 500mg
Price: $305
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0015898
Product name: VAPIN
Purity: 95.00%
Packaging: 5G
Price: $910.17
Updated: 2021/12/16

AK Scientific

Product number: 2217AH
Product name: Anisotropine methyl bromide
Packaging: 1g
Price: $64
Updated: 2021/12/16

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ANISOTROPINE METHYLBROMIDE Chemical Properties,Usage,Production

Originator

Valpin,Endo (Du Pont),US,1963

Uses

Anisotropine Methylbromide is a antichloindergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion. Anisotropine Methylbromide was found to be potentially useful in the treatment of duodenal ulcer disease.

Definition

ChEBI: A quaternary ammonium salt resulting from the reaction of the amino group of anisotropine with methyl bromide.

Manufacturing Process

Preparation of Di-n-propyl acetyl tropine hydrochloride: Tropine (11.12 grams) was dissolved in 100 ml of anhydrous pyridine and to this solution was added 15.64 grams of di-n-propyl acetyl chloride. The mixture was refluxed for 6 hours. This solution was then cooled and the pyridine removed in vacuum. The residue was dissolved in chloroform. The chloroform solution was washed with 10% hydrochloric acid to remove the residual trace of pyridine. The hydrochloride of the product ester is soluble in chloroform and is not extracted from chloroform by hydrochloric acid. This is an unexpected property.
The chloroform solution of the hydrochloride was dried over anhydrous calcium sulfate, and evaporated to dryness, leaving a semisolid residue of product ester hydrochloride. This was recrystallized from chloroform-hexane mixture, MP 186°C.
Preparation of the Anisotropine Methyl Bromide: To the acetone solution of the free base was added an acetone solution, containing an excess of methyl bromide. Within a few minutes the methobromide started to crystallize. The mixture was allowed to stand for several hours. The crystallized solid was filtered, and additional product was obtained by evaporation of the filtrate. The yield was nearly quantitative. After recrystallization from acetone, the product melted at 329°C.

brand name

Valpin (Endo).

Therapeutic Function

Anticholinergic

ANISOTROPINE METHYLBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ANISOTROPINE METHYLBROMIDE Suppliers

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80-50-2, ANISOTROPINE METHYLBROMIDERelated Search:

Bromocresol green Methyl bromide

OCTATROPINE METHYLBROMIDE

8-METHYL-3-[2-PROPYLPENTANOYLOXY]TROPINIUM BROMIDE

ANISOTROPINE METHYLBROMIDE

1-alpha-h,5-alpha-h-tropanium,3-alpha-hydroxy-8-methyl-,bromide,2-propylvale

1alphah,5alphah-tropanium,3alpha-hydroxy-8-methyl-,bromide,2-propylvalerate

2-propylpentanoyltropiniummethylbromide

3-alpha-hydroxy-8-methyl-1-alpha-h,5-alpha-h-tropaniumbromide2-propylvalera

3alpha-hydroxy-8-methyl-1alphah,5alphah-tropaniumbromide2-propylvalerate

8,8-dimethyl-3-((1-oxo-2-propylpentyl)oxy)-8-azoniabicyclo(3.2.1)octanbr

8,8-dimethyl-3-((1-oxo-2-propylpentyl)oxy)-8-azoniabicyclo(3.2.1)octanbrom

8-methyltropiniumbromide2-propylpentanoate

QSFKGMJOKUZAJM-UHFFFAOYSA-M

Octatropine

1aH,5aH-Tropanium, 3a-hydroxy-8-methyl-, bromide, 2-propylvalerate (8CI)

8-Azoniabicyclo[3.2.1]octane, 8,8-dimethyl-3-[(1-oxo-2-propylpentyl)oxy]-, bromide, (3-endo)- (9CI)

8-Azoniabicyclo[3.2.1]octane, 8,8-dimethyl-3-[(1-oxo-2-propylpentyl)oxy]-, bromide, endo-

8-Methyltropinium bromide, 2-propylvalerate (6CI, 7CI)

methyloctatropine bromide

Octatropine metylbromide

Valpin 50

Vapin

Anisotropinmethylbromid

C06830

8-methyltropiniumbromide2-propylvalerate

anisotropinemethobromide

endo-8,8-dimethyl-3-[(1-oxo-2-propylpentyl)oxy]-8-azoniabicyclo[3.2.1]octanebr

endo-id

endo-omid

lytispasm

valpin

8-Azoniabicyclo[3.2.1]octane, 8,8-dimethyl-3-[(1-oxo-2-propylpentyl)oxy]-, bromide, (3-endo)-

gastric acid,mAChR,Muscarinic acetylcholine receptor,Inhibitor,inhibit,anticholinergic,Anisotropine Methylbromide,Octatropine,peptic ulcers,Anisotropine,muscarinic

Anisotropine Methylbromide (CB-154)

80-50-2

C17H32NO2Br

C17H32BrNO2

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